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Literature DB >> 3009496

Retinoids stimulate the release of superoxide by neutrophils and change their morphology.

J A Badwey, J M Robinson, J T Curnutte, M J Karnovsky, M L Karnovsky.

Abstract

All-trans-retinal stimulated the release of superoxide by human and guinea pig neutrophils 63 +/- 14 SD and 53 +/- 5 SD nmol of O2-/min/10(7) cells, respectively. Superoxide release by unstimulated cells was negligible. All-trans-retinal also induced morphological changes (i.e., evaginations) in these cells. Other retinoids were effective in instigating these phenomena. The similarities of these effects to those instigated by cis-unsaturated fatty acids (Badwey, J.A., et al., 1984, J. Biol. Chem., 259:7870-7877) are discussed in light of possible mechanisms.

Entities: Chemical Disease Species

Mesh：

Substances：
Retinoids
Superoxides

Year: 1986 PMID： 3009496 DOI： 10.1002/jcp.1041270206

Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384

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Cited

8 in total

Review 1. Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium.

Authors: P G Heyworth; J A Badwey
Journal: J Bioenerg Biomembr Date: 1990-02 Impact factor: 2.945

2. Retinoids inhibit the respiratory burst and degranulation of stimulated human polymorphonuclear leukocytes.

Authors: R Fumarulo; M Conese; S Riccardi; D Giordano; P Montemurro; M Colucci; N Semeraro
Journal: Agents Actions Date: 1991-11

3. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

Authors: C F Nathan
Journal: J Clin Invest Date: 1987-12 Impact factor: 14.808

4. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.

Authors: Yu Chen; Kiichiro Okano; Tadao Maeda; Vishal Chauhan; Marcin Golczak; Akiko Maeda; Krzysztof Palczewski
Journal: J Biol Chem Date: 2011-12-19 Impact factor: 5.157

5. all-trans-Retinal stimulates superoxide release and phospholipase C activity in neutrophils without significantly blocking protein kinase C.

Authors: J E Lochner; J A Badwey; W Horn; M L Karnovsky
Journal: Proc Natl Acad Sci U S A Date: 1986-10 Impact factor: 11.205

Retinoids stimulate the release of superoxide by neutrophils and change their morphology.

Review 1. Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium.

2. Retinoids inhibit the respiratory burst and degranulation of stimulated human polymorphonuclear leukocytes.

3. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

4. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.

5. all-trans-Retinal stimulates superoxide release and phospholipase C activity in neutrophils without significantly blocking protein kinase C.

6. Neutrophils are immune cells preferentially targeted by retinoic acid in elderly subjects.

7. Cell surface dynamics of neutrophils stimulated with phorbol esters or retinoids.

8. Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents.