Rebecca L Ashare1, Reagan R Wetherill2. 1. Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA, 19104, USA. rlashare@pennmedicine.upenn.edu. 2. Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA, 19104, USA.
Abstract
PURPOSE OF REVIEW: Tobacco use, sex differences, and psychiatric disorders are associated with altered immune function. There are also sex differences in tobacco use and psychiatric disorders. This review summarizes findings from the small, but growing literature examining sex differences in the effects of tobacco use on inflammation and the implications for psychiatric disorders. RECENT FINDINGS: We identified four studies that tested the interaction between sex and tobacco/nicotine on inflammation. Although males and females generally exhibited differential tobacco-induced immune responses, the pattern varied depending on the sample (rodents vs. humans) and the method to evaluate inflammation. Evidence suggests that sex modulates the effects of tobacco smoke on inflammation. Many inflammation markers associated with sex differences and tobacco use are related to psychiatric disorders. We propose a model in which sex, tobacco use, and inflammation interact to increase risk for psychiatric disorders. Future studies are needed to examine the mechanisms that explain this relationship.
PURPOSE OF REVIEW: Tobacco use, sex differences, and psychiatric disorders are associated with altered immune function. There are also sex differences in tobacco use and psychiatric disorders. This review summarizes findings from the small, but growing literature examining sex differences in the effects of tobacco use on inflammation and the implications for psychiatric disorders. RECENT FINDINGS: We identified four studies that tested the interaction between sex and tobacco/nicotine on inflammation. Although males and females generally exhibited differential tobacco-induced immune responses, the pattern varied depending on the sample (rodents vs. humans) and the method to evaluate inflammation. Evidence suggests that sex modulates the effects of tobacco smoke on inflammation. Many inflammation markers associated with sex differences and tobacco use are related to psychiatric disorders. We propose a model in which sex, tobacco use, and inflammation interact to increase risk for psychiatric disorders. Future studies are needed to examine the mechanisms that explain this relationship.
Entities:
Keywords:
Immune function; Inflammation; Nicotine; Psychiatric disorders; Sex differences; Tobacco
Authors: Meredith S Shiels; Hormuzd A Katki; Neal D Freedman; Mark P Purdue; Nicolas Wentzensen; Britton Trabert; Cari M Kitahara; Michael Furr; Yan Li; Troy J Kemp; James J Goedert; Cindy M Chang; Eric A Engels; Neil E Caporaso; Ligia A Pinto; Allan Hildesheim; Anil K Chaturvedi Journal: J Natl Cancer Inst Date: 2014-10-01 Impact factor: 13.506
Authors: Janet Wozniak; Joseph Biederman; Mary Kate Martelon; Mariely Hernandez; K Yvonne Woodworth; Stephen V Faraone Journal: J Affect Disord Date: 2013-02-26 Impact factor: 4.839
Authors: Jean-Eric Ghia; Patricia Blennerhassett; Ykang Deng; Elena F Verdu; Waliul I Khan; Stephen M Collins Journal: Gastroenterology Date: 2009-03-09 Impact factor: 22.682
Authors: J R DiFranza; J A Savageau; N A Rigotti; K Fletcher; J K Ockene; A D McNeill; M Coleman; C Wood Journal: Tob Control Date: 2002-09 Impact factor: 7.552
Authors: Shivesh Ghura; Robert Gross; Kelly Jordan-Sciutto; Jacob Dubroff; Robert Schnoll; Ronald G Collman; Rebecca L Ashare Journal: J Neuroimmune Pharmacol Date: 2019-12-13 Impact factor: 4.147