The influence of semantic associations on sentence production in schizophrenia: an fMRI study.

One of the most prominent symptoms of schizophrenia is thought disorder, which manifests itself in language production difficulties. In patients with thought disorders the associations are loosened and sentence production is impaired. The determining behavioral and neural mechanisms of sentence production are still an important subject of recent research and have not yet been fully understood. The aim of the current study was to examine the influence of associative relations and distractor modalities on sentence production in healthy participants and participants with schizophrenia. Therefore, reaction times and neural activation of 12 healthy subjects and 13 subjects with schizophrenia were compared in an adapted picture word interference paradigm (PWI). No significant group differences were found, neither on the behavioral nor on the neural level. On the behavioral level, for the entire group incremental sentence processing was found, i.e. processing of the second noun only starts after the first noun was processed. At the neural level, activation was discovered in the bilateral caudate nuclei and the cerebellum. Those activations could be related to response enhancement and suppression as well as to the modulation of cognitive processes.