| Literature DB >> 30093628 |
Derek Wong1,2, Kohl Lounsbury3, Amy Lum2, Jungeun Song4, Susanna Chan4, Veronique LeBlanc4, Suganthi Chittaranjan4, Marco Marra4,5, Stephen Yip6,7.
Abstract
Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through activation of the MAPK signalling cascade and derepression of oncogenic ETS transcription factors. The Ataxin-family protein ATXN1L has previously been reported to interact with CIC in developmental and disease contexts to facilitate the repression of CIC target genes. To further investigate this relationship, we performed functional in vitro studies utilizing ATXN1LKO and CICKO human cell lines and characterized a reciprocal functional relationship between CIC and ATXN1L. Transcriptomic interrogation of the CIC-ATXN1-ATXN1L axis in low-grade glioma, prostate adenocarcinoma and stomach adenocarcinoma TCGA cohorts revealed context-dependent convergence of gene sets and pathways related to mitotic cell cycle and division. This study highlights the CIC-ATXN1-ATXN1L axis as a more potent regulator of the cell cycle than previously appreciated.Entities:
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Year: 2018 PMID： 30093628 DOI： 10.1038/s41388-018-0427-5
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867