Adolf Pfefferbaum1, Natalie M Zahr1, Stephanie A Sassoon2, Dongjin Kwon1, Kilian M Pohl2, Edith V Sullivan3. 1. Center for Health Sciences, SRI International, Menlo Park, California; Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, California. 2. Center for Health Sciences, SRI International, Menlo Park, California. 3. Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, California. Electronic address: edie@stanford.edu.
Abstract
BACKGROUND: Life expectancy of successfully treated human immunodeficiency virus (HIV)-infected individuals is approaching normal longevity. The growing HIV population ≥50 years of age is now at risk of developing HIV-associated neurocognitive disorder, acquiring coinfection with the hepatitis C virus (HCV), and engaging in hazardous drinking or drug consumption that can adversely affect trajectories of the healthy aging of brain structures. METHODS: This cross-sectional/longitudinal study quantified regional brain volumes from 1101 magnetic resonance imaging scans collected over 14 years in 549 participants (25 to 75 years of age): 68 HIV-infected individuals without alcohol dependence, 60 HIV-infected individuals with alcohol dependence, 222 alcohol-dependent individuals, and 199 control subjects. We tested 1) whether localized brain regions in HIV-infected individuals exhibited accelerated aging, or alternatively, nonaccelerated premature aging deficits; and 2) the extent to which alcohol or substance dependence or HCV coinfection altered brain aging trajectories. RESULTS: The HIV-infected cohort exhibited steeper declining volume trajectories than control subjects, consistently in the frontal cortex. Nonaccelerated volume deficits occurred in the temporal, parietal, insular, and cingulate regions of all three diagnostic groups. Alcohol and drug dependence comorbidities and HCV coinfection exacerbated HIV-related volume deficits. Accelerated age interactions in frontal and posterior parietal volumes endured in HIV-infected individuals free of alcohol or substance dependence and HCV infection comorbidities. Functionally, poorer HIV-associated neurocognitive disorder scores and Veterans Aging Cohort Study indices correlated with smaller regional brain volumes in the HIV-infected individuals without alcohol dependence and alcohol-dependent groups. CONCLUSIONS: HIV infection itself may confer a heightened risk of accelerated brain aging, potentially exacerbated by HCV coinfection and substance dependency. Confirmation would require a prospective study with a preinfection baseline.
BACKGROUND: Life expectancy of successfully treated humanimmunodeficiency virus (HIV)-infected individuals is approaching normal longevity. The growing HIV population ≥50 years of age is now at risk of developing HIV-associated neurocognitive disorder, acquiring coinfection with the hepatitis C virus (HCV), and engaging in hazardous drinking or drug consumption that can adversely affect trajectories of the healthy aging of brain structures. METHODS: This cross-sectional/longitudinal study quantified regional brain volumes from 1101 magnetic resonance imaging scans collected over 14 years in 549 participants (25 to 75 years of age): 68 HIV-infected individuals without alcohol dependence, 60 HIV-infected individuals with alcohol dependence, 222 alcohol-dependent individuals, and 199 control subjects. We tested 1) whether localized brain regions in HIV-infected individuals exhibited accelerated aging, or alternatively, nonaccelerated premature aging deficits; and 2) the extent to which alcohol or substance dependence or HCV coinfection altered brain aging trajectories. RESULTS: The HIV-infected cohort exhibited steeper declining volume trajectories than control subjects, consistently in the frontal cortex. Nonaccelerated volume deficits occurred in the temporal, parietal, insular, and cingulate regions of all three diagnostic groups. Alcohol and drug dependence comorbidities and HCV coinfection exacerbated HIV-related volume deficits. Accelerated age interactions in frontal and posterior parietal volumes endured in HIV-infected individuals free of alcohol or substance dependence and HCV infection comorbidities. Functionally, poorer HIV-associated neurocognitive disorder scores and Veterans Aging Cohort Study indices correlated with smaller regional brain volumes in the HIV-infected individuals without alcohol dependence and alcohol-dependent groups. CONCLUSIONS:HIV infection itself may confer a heightened risk of accelerated brain aging, potentially exacerbated by HCV coinfection and substance dependency. Confirmation would require a prospective study with a preinfection baseline.
Authors: Ned Sacktor; Richard L Skolasky; Eric Seaberg; Cynthia Munro; James T Becker; Eileen Martin; Ann Ragin; Andrew Levine; Eric Miller Journal: Neurology Date: 2015-12-30 Impact factor: 9.910
Authors: Kevin Robertson; Johnstone Kumwenda; Khuanchai Supparatpinyo; Jeanne H Jiang; Scott Evans; Thomas B Campbell; Richard W Price; Robert Murphy; Colin Hall; Christina M Marra; Cheryl Marcus; Baiba Berzins; Reena Masih; Breno Santos; Marcus T Silva; N Kumarasamy; Ann Walawander; Apsara Nair; Srikanth Tripathy; Cecilia Kanyama; Mina Hosseinipour; Silvia Montano; Alberto La Rosa; Farida Amod; Ian Sanne; Cindy Firnhaber; James Hakim; Pim Brouwers Journal: J Neurovirol Date: 2011-07-23 Impact factor: 2.643
Authors: Adolf Pfefferbaum; Torsten Rohlfing; Margaret J Rosenbloom; Weiwei Chu; Ian M Colrain; Edith V Sullivan Journal: Neuroimage Date: 2012-10-12 Impact factor: 6.556
Authors: Lindsay J Hines; Eric N Miller; Charles H Hinkin; Jeffery R Alger; Peter Barker; Karl Goodkin; Eileen M Martin; Victoria Maruca; Ann Ragin; Ned Sacktor; Joanne Sanders; Ola Selnes; James T Becker Journal: Brain Imaging Behav Date: 2016-09 Impact factor: 3.978
Authors: S Dawes; P Suarez; C Y Casey; M Cherner; T D Marcotte; S Letendre; I Grant; R K Heaton Journal: J Clin Exp Neuropsychol Date: 2008-03-04 Impact factor: 2.475
Authors: Xue Hua; Christina P Boyle; Jaroslaw Harezlak; David F Tate; Constantin T Yiannoutsos; Ron Cohen; Giovanni Schifitto; Assawin Gongvatana; Jianhui Zhong; Tong Zhu; Michael J Taylor; Thomas B Campbell; Eric S Daar; Jeffry R Alger; Elyse Singer; Steve Buchthal; Arthur W Toga; Bradford Navia; Paul M Thompson Journal: Neuroimage Clin Date: 2013-08-03 Impact factor: 4.881
Authors: Rosemary Fama; Anne-Pascale Le Berre; Stephanie A Sassoon; Natalie M Zahr; Kilian M Pohl; Adolf Pfefferbaum; Edith V Sullivan Journal: Brain Struct Funct Date: 2019-06-03 Impact factor: 3.270
Authors: Stephen B Asiimwe; Livia Montana; Kathleen Kahn; Stephen M Tollman; Chodziwadziwa W Kabudula; Xavier F Gómez-Olivé; Lisa F Berkman; Maria M Glymour; Till Bärnighausen Journal: J Aging Health Date: 2020-06-05
Authors: Edith V Sullivan; Ty Brumback; Susan F Tapert; Sandra A Brown; Fiona C Baker; Ian M Colrain; Devin Prouty; Michael D De Bellis; Duncan B Clark; Bonnie J Nagel; Kilian M Pohl; Adolf Pfefferbaum Journal: Biol Psychiatry Date: 2019-09-09 Impact factor: 13.382