STUDY OBJECTIVES: To determine the prevalence and clinical associations of respiratory effort-related arousals (RERA) in a general population sample. METHODS: A total of 2,162 participants (51.2% women, 58.5 ± 11.0 years old, body mass index [BMI] 25.6 ± 4.2 kg/m2) of a general population-based cohort (HypnoLaus, Switzerland) underwent full polysomnography at home. Each subject with a RERA index ≥ 5 events/h was compared with an age-, sex- and apnea-hypopnea index (AHI)-matched control without RERA. RESULTS: A RERA index ≥ 5 events/h was present in 84 participants (3.8%; 95% confidence interval: 3.2-4.8%). In 17 participants (0.8%; 95% confidence interval: 0.5-1.3%), RERAs were the predominant sleep breathing disorder and only one of them complained of excessive daytime sleepiness. Compared to matched controls, subjects with a RERA index ≥ 5 events/h were similar in terms of BMI (26.5 ± 3.5 versus 26.3 ± 4.8 kg/m2, P = .73), neck circumference (38.5 ± 3.3 versus 37.6 ± 3.7 cm, P = .10) and Epworth Sleepiness Scale score (6.7 ± 3.7 versus 6.0 ± 3.7, P = .22). Also, no differences were found for hypertension (21.4% versus 27.4%, P = .47), diabetes (7.1% versus 7.1%, P = 1.00), or metabolic syndrome (31.0% versus 23.8%, P = .39). CONCLUSIONS: In a middle-aged population-based cohort, the prevalence of a RERA index ≥ 5 events/h was low (3.8%) and was not associated with negative clinical outcomes when using the currently recommended scoring criteria of the American Academy of Sleep Medicine.
STUDY OBJECTIVES: To determine the prevalence and clinical associations of respiratory effort-related arousals (RERA) in a general population sample. METHODS: A total of 2,162 participants (51.2% women, 58.5 ± 11.0 years old, body mass index [BMI] 25.6 ± 4.2 kg/m2) of a general population-based cohort (HypnoLaus, Switzerland) underwent full polysomnography at home. Each subject with a RERA index ≥ 5 events/h was compared with an age-, sex- and apnea-hypopnea index (AHI)-matched control without RERA. RESULTS: A RERA index ≥ 5 events/h was present in 84 participants (3.8%; 95% confidence interval: 3.2-4.8%). In 17 participants (0.8%; 95% confidence interval: 0.5-1.3%), RERAs were the predominant sleep breathing disorder and only one of them complained of excessive daytime sleepiness. Compared to matched controls, subjects with a RERA index ≥ 5 events/h were similar in terms of BMI (26.5 ± 3.5 versus 26.3 ± 4.8 kg/m2, P = .73), neck circumference (38.5 ± 3.3 versus 37.6 ± 3.7 cm, P = .10) and Epworth Sleepiness Scale score (6.7 ± 3.7 versus 6.0 ± 3.7, P = .22). Also, no differences were found for hypertension (21.4% versus 27.4%, P = .47), diabetes (7.1% versus 7.1%, P = 1.00), or metabolic syndrome (31.0% versus 23.8%, P = .39). CONCLUSIONS: In a middle-aged population-based cohort, the prevalence of a RERA index ≥ 5 events/h was low (3.8%) and was not associated with negative clinical outcomes when using the currently recommended scoring criteria of the American Academy of Sleep Medicine.
Authors: Luciana O Palombini; Sergio Tufik; David M Rapoport; Indu A Ayappa; Christian Guilleminault; Luciana B M de Godoy; Laura S Castro; Lia Bittencourt Journal: Sleep Date: 2013-11-01 Impact factor: 5.849
Authors: Avram R Gold; Morris S Gold; Keith W Harris; Vidal J Espeleta; Mohammad M Amin; Joan E Broderick Journal: Sleep Med Date: 2007-11-19 Impact factor: 3.492
Authors: Steven R Coughlin; Lynn Mawdsley; Julie A Mugarza; Peter M A Calverley; John P H Wilding Journal: Eur Heart J Date: 2004-05 Impact factor: 29.983
Authors: Riccardo A Stoohs; Pierre Philip; Daniela Andries; Emily V A Finlayson; Christian Guilleminault Journal: Sleep Med Date: 2009-05-01 Impact factor: 3.492
Authors: Brian D Kent; Ludger Grote; Silke Ryan; Jean-Louis Pépin; Maria R Bonsignore; Ruzena Tkacova; Tarja Saaresranta; Johan Verbraecken; Patrick Lévy; Jan Hedner; Walter T McNicholas Journal: Chest Date: 2014-10 Impact factor: 9.410