Yoshihiko Kawano1, Jun-Ichi Kawada2, Noriko Nagai1, Yoshinori Ito2. 1. a Department of Pediatrics , Okazaki City Hospital , Okazaki , Japan. 2. b Department of Pediatrics , Nagoya University Graduate School of Medicine , Nagoya , Japan.
Abstract
Objectives: Kawasaki disease (KD) is one of the most common childhood vasculitides. Some serological studies have suggested an etiological relationship between KD and human herpesvirus (HHV)-6 or HHV-7. However, primary or reactivated HHV-6 and -7 has not been fully investigated in patients with KD. Methods: Twenty-three patients with KD were prospectively enrolled in this study. Peripheral blood was collected in the acute and convalescence phases, and HHV-6 and -7 viral loads were measured by real-time PCR. Results: In the acute phase, HHV-6 and -7 DNA was detected in 7 (30%) patients each, compared to 13 (57%) and 9 (39%) patients in the convalescence phase, respectively. HHV-6 and -7 DNA loads were significantly higher in the convalescence phase than in the acute phase. Significant increases in HHV-6 and -7 DNA loads were not observed in disease control patients. Taking into account HHV-6 and -7 serostatus, reactivation of HHV-6 and -7 was observed in 7 and 9 patients, respectively. KD patients with HHV-6 reactivation showed higher C-reactive protein levels and more frequently required steroid therapies than patients without reactivation. Conclusion: HHV-6 and -7 reactivation is frequent in KD patients. HHV-6 reactivation might exacerbate the severity of KD.
Objectives:Kawasaki disease (KD) is one of the most common childhood vasculitides. Some serological studies have suggested an etiological relationship between KD and humanherpesvirus (HHV)-6 or HHV-7. However, primary or reactivated HHV-6 and -7 has not been fully investigated in patients with KD. Methods: Twenty-three patients with KD were prospectively enrolled in this study. Peripheral blood was collected in the acute and convalescence phases, and HHV-6 and -7 viral loads were measured by real-time PCR. Results: In the acute phase, HHV-6 and -7 DNA was detected in 7 (30%) patients each, compared to 13 (57%) and 9 (39%) patients in the convalescence phase, respectively. HHV-6 and -7 DNA loads were significantly higher in the convalescence phase than in the acute phase. Significant increases in HHV-6 and -7 DNA loads were not observed in disease control patients. Taking into account HHV-6 and -7 serostatus, reactivation of HHV-6 and -7 was observed in 7 and 9 patients, respectively. KDpatients with HHV-6 reactivation showed higher C-reactive protein levels and more frequently required steroid therapies than patients without reactivation. Conclusion:HHV-6 and -7 reactivation is frequent in KDpatients. HHV-6 reactivation might exacerbate the severity of KD.
Entities:
Keywords:
Human herpesvirus 6; Kawasaki disease; human herpesvirus 7
Authors: Katia Lino; Lilian S Alves; Jessica V Raposo; Thalia Medeiros; Cintia F Souza; Andrea A da Silva; Vanessa S de Paula; Jorge R Almeida Journal: J Med Virol Date: 2021-10-19 Impact factor: 20.693
Authors: Morouge M Alramadhan; Ankur A Kamdar; Meaghan Lafferty-Prather; Elizabeth A Aguilera; Susan H Wootton Journal: Glob Pediatr Health Date: 2020-07-25