Literature DB >> 30091177

Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.

Maciej J Zamek-Gliszczynski1, Mitchell E Taub2, Paresh P Chothe3, Xiaoyan Chu4, Kathleen M Giacomini5, Richard B Kim6, Adrian S Ray7, Sophie L Stocker8, Jashvant D Unadkat9, Matthias B Wittwer10, Cindy Xia11, Sook-Wah Yee5, Lei Zhang12, Yan Zhang13.   

Abstract

This white paper provides updated International Transporter Consortium (ITC) recommendations on transporters that are important in drug development following the 3rd ITC workshop. New additions include prospective evaluation of organic cation transporter 1 (OCT1) and retrospective evaluation of organic anion transporting polypeptide (OATP)2B1 because of their important roles in drug absorption, disposition, and effects. For the first time, the ITC underscores the importance of transporters involved in drug-induced vitamin deficiency (THTR2) and those involved in the disposition of biomarkers of organ function (OAT2 and bile acid transporters).
© 2018 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2018        PMID： 30091177      PMCID： PMC8211378          DOI： 10.1002/cpt.1112

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  101 in total

Review 1.  Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings.

Authors:  Jingjing Yu; Zhu Zhou; Jessica Tay-Sontheimer; René H Levy; Isabelle Ragueneau-Majlessi
Journal:  J Pharm Sci       Date:  2017-04-13       Impact factor: 3.534

Review 2.  Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management.

Authors:  Gianpietro Sechi; Alessandro Serra
Journal:  Lancet Neurol       Date:  2007-05       Impact factor: 44.182

3.  Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.

Authors:  Kyunghee Yang; Nathan D Pfeifer; Kathleen Köck; Kim L R Brouwer
Journal:  J Pharmacol Exp Ther       Date:  2015-02-23       Impact factor: 4.030

4.  Organic anion transporting polypeptide-mediated transport of, and inhibition by, asunaprevir, an inhibitor of hepatitis C virus NS3 protease.

Authors:  T Eley; Y-H Han; S-P Huang; B He; W Li; W Bedford; M Stonier; D Gardiner; K Sims; A D Rodrigues; R J Bertz
Journal:  Clin Pharmacol Ther       Date:  2014-12-20       Impact factor: 6.875

5.  Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction.

Authors:  Jiake He; Yang Yu; Bhagwat Prasad; Xijing Chen; Jashvant D Unadkat
Journal:  Biopharm Drug Dispos       Date:  2014-03-03       Impact factor: 1.627

6.  Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

Authors:  Daisuke Kobayashi; Takashi Nozawa; Kozue Imai; Jun-ichi Nezu; Akira Tsuji; Ikumi Tamai
Journal:  J Pharmacol Exp Ther       Date:  2003-04-30       Impact factor: 4.030

7.  Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.

Authors:  Tsuyoshi Mikkaichi; Takehiro Suzuki; Tohru Onogawa; Masayuki Tanemoto; Hiroya Mizutamari; Masahiro Okada; Tatsuji Chaki; Satohiro Masuda; Taro Tokui; Nobuaki Eto; Michiaki Abe; Fumitoshi Satoh; Michiaki Unno; Takanori Hishinuma; Ken-Ichi Inui; Sadayoshi Ito; Junichi Goto; Takaaki Abe
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-01       Impact factor: 11.205

8.  Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.

Authors:  Amber Dahlin; Ethan Geier; Sophie L Stocker; Cheryl D Cropp; Elena Grigorenko; Michele Bloomer; Julie Siegenthaler; Lu Xu; Anthony S Basile; Diane D-S Tang-Liu; Kathleen M Giacomini
Journal:  Mol Pharm       Date:  2013-01-24       Impact factor: 4.939

9.  Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).

Authors:  Xiaomin Liang; Huan-Chieh Chien; Sook Wah Yee; Marilyn M Giacomini; Eugene C Chen; Meiling Piao; Jia Hao; Jolyn Twelves; Eve-Irene Lepist; Adrian S Ray; Kathleen M Giacomini
Journal:  Mol Pharm       Date:  2015-11-16       Impact factor: 4.939

10.  Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.

Authors:  Eve-Irene Lepist; Xuexiang Zhang; Jia Hao; Jane Huang; Alan Kosaka; Gabriel Birkus; Bernard P Murray; Roy Bannister; Tomas Cihlar; Yong Huang; Adrian S Ray
Journal:  Kidney Int       Date:  2014-03-19       Impact factor: 10.612
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  46 in total

Review 1.  Choroid Plexus and Drug Removal Mechanisms.

Authors:  Austin Sun; Joanne Wang
Journal:  AAPS J       Date:  2021-05-03       Impact factor: 4.009

2.  Principles and Experimental Considerations for In Vitro Transporter Interaction Assays.

Authors:  Sid Bhoopathy; Chris Bode; Vatsala Naageshwaran; Erica Weiskircher-Hildebrandt; Venkata Mukkavilli; Ismael J Hidalgo
Journal:  Methods Mol Biol       Date:  2021

Review 3.  Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion-transporting polypeptides.

Authors:  Wooin Lee; Jeong-Min Ha; Yuichi Sugiyama
Journal:  J Biol Chem       Date:  2020-10-13       Impact factor: 5.157

4.  Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices.

Authors:  Ondrej Martinec; Martin Huliciak; Frantisek Staud; Filip Cecka; Ivan Vokral; Lukas Cerveny
Journal:  Antimicrob Agents Chemother       Date:  2019-10-22       Impact factor: 5.191

5.  Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.

Authors:  Ling Zou; Joshua Pottel; Natalia Khuri; Huy X Ngo; Zhanglin Ni; Eleftheria Tsakalozou; Mark S Warren; Yong Huang; Brian K Shoichet; Kathleen M Giacomini
Journal:  Mol Pharm       Date:  2020-02-10       Impact factor: 4.939

6.  Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions.

Authors:  James J Beaudoin; Jacqueline Bezençon; Noora Sjöstedt; John K Fallon; Kim L R Brouwer
Journal:  Toxicol Sci       Date:  2020-07-01       Impact factor: 4.849

Review 7.  Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside.

Authors:  James J Beaudoin; Kim L R Brouwer; Melina M Malinen
Journal:  Pharmacol Ther       Date:  2020-04-02       Impact factor: 12.310

8.  Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.

Authors:  Sook Wah Yee; Dina Buitrago; Adrian Stecula; Huy X Ngo; Huan-Chieh Chien; Ling Zou; Megan L Koleske; Kathleen M Giacomini
Journal:  FASEB J       Date:  2020-10-30       Impact factor: 5.191

9.  The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions.

Authors:  Jasleen K Sodhi; Leslie Z Benet
Journal:  AAPS J       Date:  2020-08-17       Impact factor: 4.009

10.  Food dyes as P-glycoprotein modulators.

Authors:  Jack W Staples; Jessica M Stine; Eero Mäki-Lohiluoma; Emily Steed; Kathleen M George; Charles M Thompson; Erica L Woodahl
Journal:  Food Chem Toxicol       Date:  2020-10-01       Impact factor: 6.023
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