Literature DB >> 30090442

Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage.

Jun Li1, Lu Ma1, Xilan Wang1, Daochuan Li2, Qibing Zeng1, Xiumei Xing2, Chenggui Li1, Lang Xie1, Li Chen1, Wen Chen2, Aihua Zhang1.   

Abstract

Endemic arsenic poisoning is a worldwide disease and many studies show that arsenic has obvious genetic toxicity. However, the mechanism of arsenic-induced genetic damage is unclear. In this study, coal-fired arsenic poisoning patients in the Guizhou Province, China, were selected as research subjects. Through an analysis of the relationship between genetic damage and histone modification levels and by comparing the control and arsenic poisoning groups, further analysis of their relationship was carried out, the aim being to explore the role of histone modification in arsenic-induced genetic damage. The result shows that arsenic may inhibit the modification level of H4K20me2 and H3K9me2, and increase the modification of H3K36me3, involved in the repair of DNA damage induced by arsenic. This study could provide a new pathway for studies of the genetic toxicity of arsenic.

Entities:  

Year:  2016        PMID： 30090442      PMCID： PMC6062123          DOI： 10.1039/c6tx00117c

Source DB:  PubMed          Journal:  Toxicol Res (Camb)        ISSN： 2045-452X            Impact factor:   3.524


  22 in total

1.  Evaluation of micronucleus frequencies and DNA damage in glass workers exposed to arsenic.

Authors:  Saleha B Vuyyuri; Mohamed Ishaq; Danadevi Kuppala; Paramjit Grover; Y R Ahuja
Journal:  Environ Mol Mutagen       Date:  2006-08       Impact factor: 3.216

2.  Comparison of DNA damage by the comet assay in fresh versus cryopreserved peripheral blood mononuclear cells obtained following dietary intervention.

Authors:  Cristian Del Bo'; Daniela Fracassetti; Claudia Lanti; Marisa Porrini; Patrizia Riso
Journal:  Mutagenesis       Date:  2015-01       Impact factor: 3.000

Review 3.  Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment.

Authors:  Samuel M Cohen; Lora L Arnold; Michal Eldan; Ari S Lewis; Barbara D Beck
Journal:  Crit Rev Toxicol       Date:  2006-02       Impact factor: 5.635

Review 4.  PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription.

Authors:  David B Beck; Hisanobu Oda; Steven S Shen; Danny Reinberg
Journal:  Genes Dev       Date:  2012-02-15       Impact factor: 11.361

5.  Acetylation and methylation patterns of core histones are modified after heat or arsenite treatment of Drosophila tissue culture cells.

Authors:  A P Arrigo
Journal:  Nucleic Acids Res       Date:  1983-03-11       Impact factor: 16.971

6.  Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells.

Authors:  Ji Li; Peili Chen; Natasha Sinogeeva; Myriam Gorospe; Robert P Wersto; Francis J Chrest; Janice Barnes; Yusen Liu
Journal:  J Biol Chem       Date:  2002-10-17       Impact factor: 5.157

7.  Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells.

Authors:  T Helleday; R Nilsson; D Jenssen
Journal:  Environ Mol Mutagen       Date:  2000       Impact factor: 3.216

8.  Associations between arsenic exposure and global posttranslational histone modifications among adults in Bangladesh.

Authors:  Yana Chervona; Megan N Hall; Adriana Arita; Fen Wu; Hong Sun; Hsiang-Chi Tseng; Eunus Ali; Mohammad Nasir Uddin; Xinhua Liu; Maria Antonietta Zoroddu; Mary V Gamble; Max Costa
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2012-10-12       Impact factor: 4.254

9.  Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure.

Authors:  William Jaime Jo; Xuefeng Ren; Feixia Chu; Maria Aleshin; Henri Wintz; Alma Burlingame; Martyn Thomas Smith; Chris Dillon Vulpe; Luoping Zhang
Journal:  Toxicol Appl Pharmacol       Date:  2009-09-02       Impact factor: 4.219

10.  Inhalable metal-rich air particles and histone H3K4 dimethylation and H3K9 acetylation in a cross-sectional study of steel workers.

Authors:  Laura Cantone; Francesco Nordio; Lifang Hou; Pietro Apostoli; Matteo Bonzini; Letizia Tarantini; Laura Angelici; Valentina Bollati; Antonella Zanobetti; Joel Schwartz; Pier A Bertazzi; Andrea Baccarelli
Journal:  Environ Health Perspect       Date:  2011-03-08       Impact factor: 9.031
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  1 in total

1.  The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells.

Authors:  Ying Lv; Qian Hu; Mingyang Shi; Wen Wang; Yuancui Zheng; Zhong Yang; Liuyu Peng; Dingnian Bi; Aihua Zhang; Yong Hu
Journal:  Cell Stress Chaperones       Date:  2020-04-16       Impact factor: 3.667
  1 in total

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