Sir,I read with interest the case report by Sharma et al.[1] on the primary Ewing’s sarcoma (ES) of cranium in an Indian child. It is obvious that due to poor immunity, individuals infected with human immunodeficiency virus (HIV) are at increased risk to various neoplasms compared to the immunocompetent individuals.[2] To my knowledge, HIV infection is an important health threat in India. Although no recent data are present on the pediatric HIV seroprevalence, the available data pointed out to the substantial HIV seroprevalence rate of 1.03% among pregnant women in India.[3] Regrettably, the HIV status of the mother was unknown. I presume that some sort of vertical HIV transmission ought to be expected in the studied child. Hence, arrangement for the diagnostic set of CD4 count and viral overload estimations was envisaged in the studied child. If that diagnostic set was performed and it disclosed underlying HIV infection, the case in question could truly widen the spectrum of HIV-associated skeletal ES rarely reported in the literature.[4]