Daniela Cardinale1, Nicola Cosentino2, Marco Moltrasio2, Maria Teresa Sandri3, Francesco Petrella4, Alessandro Colombo5, Giulia Bacchiani5, Adele Tessitore4, Alice Bonomi2, Fabrizio Veglia2, Michela Salvatici6, Carlo M Cipolla5, Giancarlo Marenzi2, Lorenzo Spaggiari7. 1. Cardioncology Unit, Cardiology Division, European Institute of Oncology, Milan, Italy. Electronic address: daniela.cardinale@ieo.it. 2. Centro Cardiologico Monzino, I.R.C.C.S, Milan, University of Milan, Italy. 3. Laboratory Medicine Unit of the European Institute of Oncology, Milan, Italy; Centro Cardiologico Monzino, I.R.C.C.S, Milan, University of Milan, Italy. 4. Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy. 5. Cardioncology Unit, Cardiology Division, European Institute of Oncology, Milan, Italy. 6. Laboratory Medicine Unit of the European Institute of Oncology, Milan, Italy. 7. Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy; Department of Oncology and Hematoncology, University of Milan, Italy.
Abstract
BACKGROUND: Acute kidney injury (AKI) frequently occurs in several medical and surgical settings, and it is associated with increased morbidity and mortality. In patients undergoing lung cancer surgery, AKI has not been fully investigated. We prospectively evaluated the incidence, clinical relevance, and risk factors of AKI in patients undergoing lung cancer surgery. Moreover, we estimated the accuracy of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the prediction of AKI. METHODS: Patients undergoing lung cancer surgery were included in the study. Plasma NT-proBNP was measured before and soon after surgery. Postoperative AKI was defined according to the Acute Kidney Injury Network (AKIN) classification. RESULTS: A total of 2179 patients were enrolled. Of them, 222 (10%) developed AKI and had a more complicated in-hospital clinical course (overall complication rate: 35% vs. 16%; P < 0.0001), and a longer hospital stay (10 ± 7 vs. 7 ± 4 days; P < 0.0001). The incidence of AKI increased in parallel with the extent of lung resection. Among the independent predictors of AKI, serum creatinine (area under the curve [AUC] 0.70 [95% CI 0.67-0.74]) and NT-proBNP (AUC 0.71 [95% CI 0.67-0.74]) provided the highest predictive accuracy, and their combination further significantly improved AKI prediction (AUC 0.74 [95% CI 0.71-0.77]). No difference in AKI prediction was observed between preoperative and postoperative NT-proBNP (P = 0.84). CONCLUSIONS: Acute kidney injury occurs in 10% of patients undergoing lung cancer surgery, and it is associated with a high incidence of postoperative complications. The risk of AKI can be accurately predicted by the combined evaluation of preoperative serum creatinine and NT-proBNP.
BACKGROUND:Acute kidney injury (AKI) frequently occurs in several medical and surgical settings, and it is associated with increased morbidity and mortality. In patients undergoing lung cancer surgery, AKI has not been fully investigated. We prospectively evaluated the incidence, clinical relevance, and risk factors of AKI in patients undergoing lung cancer surgery. Moreover, we estimated the accuracy of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the prediction of AKI. METHODS:Patients undergoing lung cancer surgery were included in the study. Plasma NT-proBNP was measured before and soon after surgery. Postoperative AKI was defined according to the Acute Kidney Injury Network (AKIN) classification. RESULTS: A total of 2179 patients were enrolled. Of them, 222 (10%) developed AKI and had a more complicated in-hospital clinical course (overall complication rate: 35% vs. 16%; P < 0.0001), and a longer hospital stay (10 ± 7 vs. 7 ± 4 days; P < 0.0001). The incidence of AKI increased in parallel with the extent of lung resection. Among the independent predictors of AKI, serum creatinine (area under the curve [AUC] 0.70 [95% CI 0.67-0.74]) and NT-proBNP (AUC 0.71 [95% CI 0.67-0.74]) provided the highest predictive accuracy, and their combination further significantly improved AKI prediction (AUC 0.74 [95% CI 0.71-0.77]). No difference in AKI prediction was observed between preoperative and postoperative NT-proBNP (P = 0.84). CONCLUSIONS:Acute kidney injury occurs in 10% of patients undergoing lung cancer surgery, and it is associated with a high incidence of postoperative complications. The risk of AKI can be accurately predicted by the combined evaluation of preoperative serum creatinine and NT-proBNP.
Authors: Eric S Wise; Kyle M Hocking; Monica E Polcz; Gregory J Beilman; Colleen M Brophy; Jenna H Sobey; Philip J Leisy; Roy K Kiberenge; Bret D Alvis Journal: Anesthesiology Date: 2021-04-01 Impact factor: 7.892
Authors: Vinci Naruka; Mikel Alexander McKie; Navid Ahmadi; E A Claudia Pama; Aman S Coonar; Merits Collaborators Journal: BMJ Open Date: 2022-09-27 Impact factor: 3.006
Authors: Semin Cho; Eunjeong Kang; Ji Eun Kim; U Kang; Hee Gyung Kang; Minsu Park; Kwangsoo Kim; Dong Ki Kim; Kwon Wook Joo; Yon Su Kim; Hyung-Jin Yoon; Hajeong Lee Journal: Cancer Res Treat Date: 2021-01-18 Impact factor: 4.679