| Literature DB >> 3008948 |
T Mennini, M Gobbi, S Romandini.
Abstract
The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H] muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.Entities:
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Year: 1986 PMID： 3008948 DOI： 10.1016/0006-8993(86)90378-1
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252