Literature DB >> 30089238

A Mitochondrial Checkpoint in Autoimmune Disease.

Cornelia M Weyand1, Jörg J Goronzy2.   

Abstract

Cell-fate decisions in innate and adaptive immune cells are metabolically regulated and modified by tissue-derived signals, thereby balancing protective and pathogenic immunity. Reporting in Science, Ling et al. (2018) have identified C1q as a mitochondrial activator that suppresses exuberant anti-self and anti-viral CD8 T cell effector responses to prevent autoimmune disease.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30089238      PMCID： PMC6487495          DOI： 10.1016/j.cmet.2018.07.014

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.

Authors:  Nikhil S Joshi; Weiguo Cui; Anmol Chandele; Heung Kyu Lee; David R Urso; James Hagman; Laurent Gapin; Susan M Kaech
Journal:  Immunity       Date:  2007-08       Impact factor: 31.745

Review 2.  New insights into the immunopathogenesis of systemic lupus erythematosus.

Authors:  George C Tsokos; Mindy S Lo; Patricia Costa Reis; Kathleen E Sullivan
Journal:  Nat Rev Rheumatol       Date:  2016-11-22       Impact factor: 20.543

3.  Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.

Authors:  Gerritje J W van der Windt; Bart Everts; Chih-Hao Chang; Jonathan D Curtis; Tori C Freitas; Eyal Amiel; Edward J Pearce; Erika L Pearce
Journal:  Immunity       Date:  2011-12-28       Impact factor: 31.745

4.  Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation.

Authors:  Markus Zeisbrich; Rolando E Yanes; Hui Zhang; Ryu Watanabe; Yinyin Li; Lukas Brosig; Jison Hong; Barbara B Wallis; John C Giacomini; Themistocles L Assimes; Jörg J Goronzy; Cornelia M Weyand
Journal:  Ann Rheum Dis       Date:  2018-02-03       Impact factor: 19.103

Review 5.  Redox-sensitive signaling in inflammatory T cells and in autoimmune disease.

Authors:  Cornelia M Weyand; Yi Shen; Jorg J Goronzy
Journal:  Free Radic Biol Med       Date:  2018-03-07       Impact factor: 7.376

Review 6.  Unraveling the Complex Interplay Between T Cell Metabolism and Function.

Authors:  Ramon I Klein Geltink; Ryan L Kyle; Erika L Pearce
Journal:  Annu Rev Immunol       Date:  2018-04-26       Impact factor: 28.527

Review 7.  Nutrients and the microenvironment to feed a T cell army.

Authors:  Marc O Johnson; Peter J Siska; Diana C Contreras; Jeffrey C Rathmell
Journal:  Semin Immunol       Date:  2016-10-03       Impact factor: 11.130

8.  C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism.

Authors:  Guang Sheng Ling; Greg Crawford; Norzawani Buang; Istvan Bartok; Kunyuan Tian; Nicole M Thielens; Isabelle Bally; James A Harker; Philip G Ashton-Rickardt; Sophie Rutschmann; Jessica Strid; Marina Botto
Journal:  Science       Date:  2018-05-04       Impact factor: 47.728

9.  Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.

Authors:  Zhen Yang; Yi Shen; Hisashi Oishi; Eric L Matteson; Lu Tian; Jörg J Goronzy; Cornelia M Weyand
Journal:  Sci Transl Med       Date:  2016-03-23       Impact factor: 17.956

10.  Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells.

Authors:  Yi Shen; Zhenke Wen; Yinyin Li; Eric L Matteson; Jison Hong; Jörg J Goronzy; Cornelia M Weyand
Journal:  Nat Immunol       Date:  2017-07-24       Impact factor: 25.606
  10 in total
  5 in total

Review 1.  The role of mitochondria in rheumatic diseases.

Authors:  Yann L C Becker; Bhargavi Duvvuri; Paul R Fortin; Christian Lood; Eric Boilard
Journal:  Nat Rev Rheumatol       Date:  2022-09-29       Impact factor: 32.286

Review 2.  Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions.

Authors:  Maryam Masoumi; Samira Alesaeidi; Hossein Khorramdelazad; Mousa Behzadi; Rasoul Baharlou; Shahin Alizadeh-Fanalou; Jafar Karami
Journal:  Inflammation       Date:  2022-10-10       Impact factor: 4.657

Review 3.  Influence of immune aging on vaccine responses.

Authors:  Claire E Gustafson; Chulwoo Kim; Cornelia M Weyand; Jörg J Goronzy
Journal:  J Allergy Clin Immunol       Date:  2020-05       Impact factor: 10.793

4.  Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.

Authors:  Mahmoud AbuEid; Donna M McAllister; Laura McOlash; Megan Cleland Harwig; Gang Cheng; Donovan Drouillard; Kathleen A Boyle; Micael Hardy; Jacek Zielonka; Bryon D Johnson; R Blake Hill; Balaraman Kalyanaraman; Michael B Dwinell
Journal:  iScience       Date:  2021-05-25

Review 5.  The metabolic signature of T cells in rheumatoid arthritis.

Authors:  Cornelia M Weyand; Bowen Wu; Jörg J Goronzy
Journal:  Curr Opin Rheumatol       Date:  2020-03       Impact factor: 4.941
  5 in total

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