Literature DB >> 3008912

Adenosine inhibits locus coeruleus neurons: an intracellular study in a rat brain slice preparation.

S A Shefner, T H Chiu.   

Abstract

Intracellular recording was used to study the effect of adenosine (3-100 microM) on rat locus coeruleus (LC) neurons in a brain slice preparation. Bath application of adenosine (100 microM) reduced the rate of spontaneous firing in 88% of LC neurons. In some LC neurons adenosine also caused membrane hyperpolarization (2-10 mV) and reductions in input resistance of 9-24%. Adenosine effects were dose-dependent and antagonized by the adenosine receptor antagonist theophylline.

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Year:  1986        PMID： 3008912     DOI： 10.1016/0006-8993(86)91320-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Functional coupling between neurons and glia.

Authors:  V Alvarez-Maubecin; F Garcia-Hernandez; J T Williams; E J Van Bockstaele
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

2.  gamma-Aminobutyric acid responses in rat locus coeruleus neurones in vitro: a current-clamp and voltage-clamp study.

Authors:  S S Osmanović; S A Shefner
Journal:  J Physiol       Date:  1990-02       Impact factor: 5.182

3.  Electrophysiological actions of alfentanil: intracellular studies in the rat locus coeruleus neurones.

Authors:  T H Chiu; M H Yeh; S K Tsai; M S Mok
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

4.  Inhibitory adenosine A1-receptors on rat locus coeruleus neurones. An intracellular electrophysiological study.

Authors:  J T Regenold; P Illes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-03       Impact factor: 3.000

5.  Operational characteristics of somatostatin receptors mediating inhibitory actions on rat locus coeruleus neurones.

Authors:  I P Chessell; M D Black; W Feniuk; P P Humphrey
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739

6.  Ilex paraguariensis Promotes Orofacial Pain Relief After Formalin Injection: Involvement of Noradrenergic Pathway.

Authors:  Eudislaine Fonseca de Carvalho; Simone Kobe de Oliveira; Viviane Koepp Nardi; Tathiana Carla Gelinski; Marcelo Carlos Bortoluzzi; Marcelo Maraschin; Geisson Marcos Nardi
Journal:  Pharmacognosy Res       Date:  2016-03

Review 7.  The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy.

Authors:  Benton Purnell; Madhuvika Murugan; Raja Jani; Detlev Boison
Journal:  Front Neurosci       Date:  2021-07-12       Impact factor: 4.677
  7 in total

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