Literature DB >> 30087152

Scurvy: still a threat in the well-fed first world?

Giulia Ceglie1, Giulia Macchiarulo1, Maria Rosaria Marchili2, Alessandra Marchesi2, Lelia Rotondi Aufiero2, Chiara Di Camillo2, Alberto Villani2.   

Abstract

We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Two had vitamin D deficiency, and all had microcytic anaemia (in one case requiring transfusional support). A nutritional screening revealed low or undetectable levels of ascorbic acid. This, along with the clinical and radiological findings, led to a diagnosis of scurvy. Vitamin C supplementation was started with rapid improvement of the children's clinical condition. Scurvy is a rare disease in the 'first world', but there are anecdotal reports of scurvy in children without any of the known risk factors for this condition. In our cases, a selective diet was the only risk factor. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  collagen disorders; general paediatrics; growth; nutrition; obesity

Year:  2018        PMID: 30087152     DOI: 10.1136/archdischild-2018-315496

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN: 0003-9888            Impact factor:   3.791


  9 in total

1.  Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage.

Authors:  Zuo Hang Yu; Christopher J Reinhardt; Thomas Hin-Fung Wong; Ka Yan Tong; Jefferson Chan; Ho Yu Au-Yeung
Journal:  Chemistry       Date:  2020-06-25       Impact factor: 5.236

2.  Is it leukemia, doctor? No, it's scurvy induced by an ARFID!

Authors:  Sarah Benezech; Chrystele Hartmann; Diane Morfin; Yves Bertrand; Carine Domenech
Journal:  Eur J Clin Nutr       Date:  2020-04-20       Impact factor: 4.016

3.  Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease.

Authors:  Nattaphorn Hongsawong; Notethasoung Chawprang; Kulnipa Kittisakmontri; Parach Vittayananan; Konggrapun Srisuwan; Wattana Chartapisak
Journal:  Pediatr Nephrol       Date:  2020-07-19       Impact factor: 3.714

4.  Old Era Continues in Modern World: A Case Report of Scurvy Induced Myopathy in Patient with Chronic Alcoholism.

Authors:  Girish Singhania; Namrata Singhania; Neha Chawla
Journal:  Case Rep Med       Date:  2020-04-09

Review 5.  Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective.

Authors:  Anitra C Carr; Sam Rowe
Journal:  Nutrients       Date:  2020-07-01       Impact factor: 5.717

6.  Vitamin C epigenetically controls osteogenesis and bone mineralization.

Authors:  Roman Thaler; Farzaneh Khani; Ines Sturmlechner; Sharareh S Dehghani; Janet M Denbeigh; Xianhu Zhou; Oksana Pichurin; Amel Dudakovic; Sofia S Jerez; Jian Zhong; Jeong-Heon Lee; Ramesh Natarajan; Ivo Kalajzic; Yong-Hui Jiang; David R Deyle; Eleftherios P Paschalis; Barbara M Misof; Tamas Ordog; Andre J van Wijnen
Journal:  Nat Commun       Date:  2022-10-06       Impact factor: 17.694

7.  Scurvy: A New Old Cause of Skeletal Pain in Young Children.

Authors:  Christel Chalouhi; Nayla Nicolas; Nancy Vegas; Soraya Matczak; Houmam El Jurdi; Nathalie Boddaert; Véronique Abadie
Journal:  Front Pediatr       Date:  2020-01-31       Impact factor: 3.418

Review 8.  A Narrative Review on Pediatric Scurvy: The Last Twenty Years.

Authors:  Sandra Trapani; Chiara Rubino; Giuseppe Indolfi; Paolo Lionetti
Journal:  Nutrients       Date:  2022-02-06       Impact factor: 5.717

9.  Scurvy as an Alarm Bell of Autistic Spectrum Disorder in the First World: A Case Report of a 3-Year-Old Girl.

Authors:  Maria Liuzzo Scorpo; Giovanni Corsello; Maria Cristina Maggio
Journal:  Am J Case Rep       Date:  2021-08-02
  9 in total

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