| Literature DB >> 30086987 |
Shan Shan H Wang1, Pascal S Kaeser2.
Abstract
How are synaptic vesicles tied together in a nerve terminal? A recent study by Milovanovic and colleagues offers a new mechanism for this old and important problem: synapsin proteins establish a liquid phase that clusters vesicles. Liquid-liquid phase separation provides a fluid-like state that accommodates the dynamic demands of presynaptic vesicle traffic.Keywords: active zone; phase separation; synapse; synapsin; synaptic vesicle; vesicle tethering
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Year: 2018 PMID： 30086987 DOI： 10.1016/j.tins.2018.07.009
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837