Transradial Approach for Aortoiliac and Femoropopliteal Interventions: A Systematic Review and Meta-analysis.

PURPOSE: To present a systematic review and meta-analysis comparing the transradial approach for aortoiliac and femoropopliteal interventions to the traditional transfemoral access.
METHODS: A search of the public domain databases MEDLINE, SCOPUS, Web of Science, and Cochrane Library Databases was performed to identify studies related to the use of the transradial approach for infra-aortic procedures. Meta-analysis was used to compare the transradial to the transfemoral route in terms of procedure success, complications, procedure parameters, and hospital length of stay. Results are presented as the odds ratio (OR) and 95% confidence interval (CI).
RESULTS: Nineteen studies containing 638 patients with transradial access for lower limb interventions were selected. Lesions were treated from the aortic bifurcation down to the popliteal artery. The mean technical success rate was 90.9%, conversion to a transfemoral approach was necessary in 9.9%, and complications were reported in 1.9%. The meta-analysis included 4 comparative studies involving 114 transradial and 208 transfemoral procedures. There was no significant advantage of either approach in terms of procedure success (OR 5.0, 95% CI 0.49 to 50.83, p=0.17), but the risk of developing a complication was significantly lower (OR 0.25, 95% CI 0.07 to 0.86, p=0.03) with the transradial approach.
CONCLUSION: Transradial access for lower limb endovascular interventions can be performed with comparable technical success and a lower overall complication profile compared to transfemoral access.

Introduction

In 1989, the first studies were published in which the radial artery was used as an access vessel for percutaneous coronary angiography and intervention.[1] Today, radial artery access has largely replaced the femoral artery as standard access for coronary interventions because it reduces by up to 60% the access-site complications, such as hemorrhage, hematoma, vascular closure device (VCD) failure, or major embolic events.[2] Furthermore, transradial access has the same technical success rates as transfemoral access and shorter hospitalization[3] in percutaneous coronary interventions. Large randomized trials comparing femoral and radial access even reported an increased overall survival in patients with acute coronary syndrome who were treated via the radial artery.[2]

Owing to its reduced risk of access-related complications in coronary interventions, the transradial route became more popular over time, and smaller devices were produced. This device development created the opportunity to treat noncoronary lesions in a variety of settings, including renal/visceral interventions, uterine artery embolization, peripheral interventions, and endoleak repair among others, with high technical success and a low incidence of major (eg, pseudoaneurysm and seizure, 0.13%) and minor (eg, hematoma, radial artery occlusion or spasm, arm pain, 2.4%) complications.[4]

It is common to perform peripheral aortoiliac interventions through the contralateral femoral artery,[5,6] but current guidelines do not indicate a preferred access artery.[7] Over the past few years, use of transradial and transulnar access in aortoiliac and infrainguinal procedures has grown despite its disadvantages,[8,9] such as the long learning curve, challenges owing to a tortuous subclavian artery or aortic arch, and the passage of devices to the target vessel over longer distances through smaller arteries.

To evaluate if the transradial route in infra-aortic interventions has similar advantages to those documented for coronary procedures a systematic review and meta-analysis were conducted to assess the efficacy and safety of transradial access in the management of aortoiliac, femoral, and popliteal artery disease.

Methods

Search Strategy

This systematic review assembled clinical evidence using a prespecified protocol and an explicit, reproducible plan for literature search and synthesis as recommended by the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines.[10]

The MEDLINE (PubMed platform), SCOPUS Web of Science, and the Cochrane Library databases were searched by 2 authors (M.M.M., E.M.) up to April 30, 2017, using the following free text and medical subject headings [MeSH]: lower extremities, lower limb, iliac, profunda, popliteal, femoralis, tibiofibularis, tibialis, fibularis, dorsalis pedis artery, peripheral vascular interventions, side effects, feasibility, safety, complications, Endovascular Procedures [MeSH], Atherectomy [MeSH], transradial, radial access, radial approach, radial artery, Radial Artery [MeSH], transradial, transulnar, ulnar artery and Ulnar Artery [MeSH]. No linguistic or geographic filters were applied in the search. The database search was supplemented by a manual search of the reference lists of the included studies the “related articles” function provided in each database.

Selection Criteria

Study inclusion was performed at 2 levels by 2 authors (M.M.M., E.M.) using predefined inclusion and exclusion criteria. Any disagreements at any stage were resolved by consensus with a senior author (A.M.T.L.C.). For each eligible study, data elements were extracted from full-text versions by one author and a second author verified the extractions with the original sources.

Articles suitable for selection were randomized controlled trials, non-randomized controlled trials, other prospective cohort studies, and observational studies. Studies involving routes other than the transradial or the transulnar for infra-aortic revascularization, technical aspects of the transradial access, animal studies, and non–English language articles were excluded.

Data Collection

Two authors (M.M.M., E.M.) independently extracted the following data from each included study: first author, year, and type of publication; size of study population; severity of peripheral artery disease as determined by Fontaine or Rutherford classification; morphology and characteristics; treated target vessel; degree of vessel stenosis as determined by angiographic assessment; radial artery access site; need for >1 percutaneous approach or conversion to transfemoral access; maximal sheath size; maximal wire length; and stent type. Data was also retrieved on the following outcomes: angiographic success at completion of intervention; closure technique; peri-interventional anticoagulation therapy; angiographic patency of revascularized target lesion at follow-up; major and minor complications; radial artery patency on completion of procedure and at the end of follow-up; hospital length of stay (LOS); and reasons for unsuccessful procedures. All data were extracted or extrapolated from text, tables, and figures. Primary outcomes were procedure success and complications; secondary outcomes were LOS, fluoroscopy and procedure times, and contrast volume.

Statistical Analysis

The meta-analysis included studies specifically comparing the transradial access with the transfemoral access for endovascular revascularization in the aortoiliac and femoropopliteal segments. Pooled meta-analysis was performed for all complications [bleeding, VCD failure, pseudoaneurysm, arteriovenous (AV) fistulas, hematoma >5 cm, death, stroke, radial artery rupture], procedure success, LOS, procedure and fluoroscopy times, and contrast volume.

Random-effects meta-analyses were performed using the Mantel-Haenszel method for dichotomous data to estimate pooled odds ratios (OR) or mean differences (MD). Statistical heterogeneity was assessed using I2 statistics. Methodological quality of all included studies was assessed using the checklist recommended by the 9-point Newcastle Ottawa scale (NOS).[11] The meta-analysis was run in RevMan (version 5.3; The Cochrane Collaboration; http://community.cochrane.org/help/tools-and-software/revman-5).

Results

Study Selection

The search identified 279 articles (Figure 1), which were culled to 176 potentially eligible studies after removing duplicates. One article[12] was added from a manual search of references. In all 149 studies were excluded after review of their titles and abstracts owing mainly to (1) revascularization of arteries other than those specified in the study protocol, (2) the use of other access methods for infra-aortic interventions, and (3) studies on the effectiveness of different stents in peripheral interventions. Among the 27 studies remaining, 2 studies were excluded because the full article was in Chinese[13] or was not available,[14] and 5 reviews[12,15-18] were excluded because they were narrative or focused on technical aspects of transradial access and did not contain patient data. The final excluded article focused on transradial angiography and stenting of noncoronary arteries but did not present the results separately per treated vessel, making it impossible to differentiate between renovisceral and infra-aortic interventions.[19]

Figure 1.

Flowchart of the systematic review.

The final systematic review included 19 studies[8,9,20-36] (4 prospective cohort studies, 1 retrospective matched cohort study, 3 retrospective cohort studies, 2 case-control studies, 3 case series, and 6 case reports). All studies were hospital-based and consisted of either vascular surgery patients or individuals presenting to a vascular clinic for follow-up. Study sample size ranged from 1 to 156 patients. Four studies[20-23] were eligible for the comparative meta-analysis; these 4 studies had a NOS score 7 to 9 out of a maximum of 9 (Table 1). For the 10 cohort/case-control studies the mean NOS was 6.7.

Table 1.

Patient Characteristics and Quality Assessment.

First Author	N	Men, %	BMI,[a] kg/m2	Fontaine	Rutherford	Lesion Location	Occlusion, %	NOS
Trani 2009[22]	12	NR	NR	8: 2b4: 3	NR	SFA	NR	7
Staniloae 2010[21]	27	63	27.9[a]	NR	2.9[a]	CIA, EIA	27	8
Cortese 2012[20]	21	53	NR	NR	13: 2/38: 4/5	IA	25	9
Roy 2016[23]	54	61	25.3[a]	NR	23: 2, 21: 3, 7: 4, 3: 5	AB, CFA, IA, SFA, PopA	41	7
Lorenzoni 2011[33]	25	56	NR	NR	NR	EIA, CIA, CFA, SFA, PopA	25	5
Cortese 2014[36]	147	76	NR	NR	121: 2–4, 28: 5/6	CIA, EIA	NR	6
Lorenzoni 2014[25]	110	80	NR	NR	NR	SFA	22	6
Shinozaki 2014[24]	30	70	NR	12: 1,19: 2,1: 3	NR	IA	NR	4
Coscas 2015[8]	24	98	4 >30	NR	NR	CFA, IA, SFA, PopA	NR	6
Ruzsa 2016[9]	156	70	25.9[a]	12:2a, 92: 2b, 28: 3, 19: 4	NR	EIA, CFA, CIA	NR	3
Flachskampf 2005[32]	1	100	NR	2b	NR	CIA	33	—
Staniloae 2006[31]	1	0	NR	NR	NR	CIA	NR	—
Watanabe 2007[27]	3	66	NR	1: 1, 1: 2, 1: 3	NR	EIA, CIA	NR
Sanghvi 2008[28]	14	66	26.9[a]	NR	NR	IA, SFA	NR	—
Trani 2010[35]	2	100	NR	2b	NR	SFA	NR	—
Pitta 2011[29]	1	100	NR	2b	NR	CIA	NR	—
Antov 2013[30]	6	100	26.9[a]	NR	3: 3, 3: 4	CIA, SFA	77
Harruna 2013[26]	1	100	NR	2b	NR	CIA	NR	—
Shinozaki 2016[34]	1	100	NR	NR	NR	EIA	100	—

Abbreviations: AB, aortic bifurcation; BMI, body mass index; CFA, common femoral artery; CIA, common iliac artery; EIA, external iliac artery; IA, iliac artery; NOS, Newcastle Ottawa scale (maximum score 9); NR; not reported; PopA, popliteal artery; SFA, superficial femoral artery.

Mean value.

Patient and Lesion Characteristics

A total of 638 patients underwent infra-aortic interventions via the transradial access for lesions involving the aortic bifurcation (n=4),[23] external iliac artery (EIA; n=23),[9,21,27,33,34,36] common iliac artery (CIA; n=295),[9,20,21,23,24,26-33,36] common femoral artery (CFA; n=16),[8,9,23,33] superficial femoral artery (SFA; n=57),[8,22,23,25,28,30,33,35] or popliteal artery (n=8),[8,23,33] though not all 19 studies reported the exact location of the treated vessel. Of 865 lesions treated, 146 (16.9%) were occlusions.

Severity of presenting symptoms was reported as either the Fontaine classification or Rutherford categories in 13 studies[9,20-24,26,27,29,30,32,35,36] comprising 363 patients. Fontaine classifications ranged from I to IV and Rutherford categories ranged from 2 to 6 (Table 1). Presentation of the Rutherford category differed among the studies. Only Staniloae et al[21] presented the Rutherford data as a mean value (Table 1).

Radial Access

Eleven articles reported a rationale as to why radial access was performed.[8,9,21,23,24-26,28-30,32] Reasons were patient or interventional characteristics, such as obesity, absent iliac pulses, severe SFA disease, inability to remain supine, expectation of difficulties with femoral approach, the use of antegrade angiography, and downstream protection. Two studies treated all patients via the radial artery when it was patent and a sheath with a sufficient length was available.[9,29] The other studies based their access choice on the experience of the interventionist.

Radial access side was reported in 18 studies. The left radial artery was utilized in 14 studies[8,9,21-23,24,25,27-29,31,33-35] comprising 223 patients and the right radial artery was utilized in 9 studies[8,20,22,23,26,30,32,33,35] comprising 224 patients. Some studies did not report access side for all patients. Among all 19 studies, 63 (9.9%) patients required conversion to the transfemoral approach or needed >1 percutaneous approach.[8,9,20,21,23,25,28,36]

Interventional Characteristics

Most studies reported the maximum sheath size (Table 2), which was 6-F in 12 studies, 7-F in 4,[28-30] and 5-F in 1 case.[26] The guidewire length was reported in the same studies. The most commonly used guidewire length was 300 cm (105 cm,[27] 120 cm,[24] 125 cm,[9,32] 260 cm,[8,20] and 300 to 400 cm.[25]) Self-expanding stents were used in 11 studies[8,9,22,24,25,28,30,31,33,35,36] and balloon-expandable stents in 10 studies.[8,9,20,25-27,29-32,36] When reported, hemostasis was always achieved by manual compression,[9,29,31] compression bandage,[20,22,28,31,35] or by using a compression device.[23,25,29,33] Post-interventional anticoagulation was reported in 10 studies[8,9,20,22,25,26,31-33,36]; in these dual antiplatelet therapy was prescribed for 1 to 3 months. More detailed data on interventional materials are available in Supplementary Table 1 (available in the online version of the article).

Table 2.

Procedure Characteristics.

First Author	Maximum Sheath Size, F	Maximum Guidewire Length, cm	Closure Technique	Periprocedural Anticoagulation	Reasons for Failure
Trani 2009[22]	6	300	Compression bandage	Dual AP 1 mo	NFP
Staniloae 2010[21]	6	300	NR	NR	N=3, twice not able to cross the lesion, once tortuosity of the subclavian artery
Cortese 2012[20]	6	260	Common bandage for 3 h	Dual AP 1 mo, lifelong aspirin	NFP
Roy 2016[23]	NR	NR	TR band	NR	NFP
Lorenzoni 2011[33]	6	300	TR band	Dual AP 1 mo	N=6, not able to cross the lesion
Cortese 2014[36]	7	300	NR	Dual AP 1 mo, lifelong aspirin	N=2, not able to cross the lesion
Lorenzoni 2014[25]	8.5	400	Compression and TR band	Dual AP for 3 mo	NR
Shinozaki 2014[24]	6	120	NR	NR	NFP
Coscas 2015[8]	6	260	Compression for 10 min	Dual AP for 2 mo, lifelong aspirin or clopidogrel	N=2, one due to spasm, one not able to cross
Ruzsa 2016[9]	8.5	125	NR	Dual AP	NR
Flachskampf 2005[32]	6	125	Compression	Dual AP 1 mo	NFP
Staniloae 2006[31]	7	300	Compression bandage	Dual AP
Watanabe 2007[27]	6	105	NR	NR	NFP
Sanghvi 2008[28]	6	300	Compression bandage	NR	N=1, not able to reach distal SFA due to short sheath
Trani 2010[35]	6	300	Elastic bandage for 6 h	NR	NFP
Pitta 2011[29]	7	300	TR band	NR	NFP
Antov 2013[30]	7	300	Compression	NR	NFP
Harruna 2013[26]	8	300	NR	Dual AP	NFP
Shinozaki 2016[34]	6	300	NR	NR	NFP

Abbreviations: AP, antiplatelet drug; NFP, no failed procedure; NR, not reported; SFA, superficial femoral artery; TR, transradial.

Procedure Success

This outcome, defined as angiographic stenosis <30% after intervention, was reported in 17 studies[8,9,20-22,24-26,28-36] and ranged from 81% to 100% (Table 3) and the mean success rate was 90.9%. Five studies[9,21,25,33,36] reported the most common reason for unsuccessful procedures, which was the inability to cross the lesion. Only 1 study[28] reported an unsuccessful intervention because the sheath was too short to reach a lesion, which was located distal in the SFA. The mean fluoroscopy time (Table 3) was 25.8 minutes[8,9,20-24,28,30,36] and the mean procedure time was 242 minutes.[8,9,20,21,23,24,28,30,36] Total contrast dosage ranged from 20 to 430 mL. The hospital LOS ranged from discharge on the same day of the procedure to 4 days postprocedure.[9,20,21,23,24,27,30,31,32,34,36] The mean time until discharge was 2.3 days.

Table 3.

Primary and Secondary Outcomes of the Included Studies.

		Primary Outcomes		Secondary Outcomes[b]
First Author	N	Procedure Success, %	Complications[a]	Fluoroscopy Time, min	Procedure Time, min	Contrast, mL	LOS, d
Trani 2009[22]	12	100	0	19±4		170±59	2.2±0.4
Staniloae 2010[21]	27	88	0	30.4	97.9	238.7	0.6
Cortese 2012[20]	21	100	0	11±6	60±32	97±78	3.1±0.6
Roy 2016[23]	54		2	14.6±11.8	46.8±25.1	132.1±98.2	2.06±0.3
Lorenzoni 2011[33]	25	84	1
Cortese 2014[36]	147	99	5	16	64	153	2.8±1.4
Lorenzoni 2014[25]	110	91	18
Shinozaki 2014[24]	30	100	0	20.5±6.5	60.4±17.4	104.5±27.4	2.1±1.1
Coscas 2015[8]	24	91	7	9	45	40
Ruzsa 2016[9]	156	99	13	7.5±1.1	25.8±3.5	98.3±10.9	2.0±0.4
Flachskampf 2005[32]	1	100	0				1
Staniloae 2006[31]	1	100	0
Watanabe 2007[27]	3		0				1
Sanghvi 2008[28]	14	93	0	31	106	220
Trani 2010[35]	2	100	0
Pitta 2011[29]	1	100	0
Antov 2013[30]	6	100	0	35	82.66	338.3	1.33
Harruna 2013[26]	1	100	0
Shinozaki 2016[34]	1	100	0				1

Abbreviation: LOS, length of stay.

Includes bleeding, vascular closure device failure, pseudoaneurysm, arteriovenous fistulas, hematoma >5 cm, death, stroke, radial artery rupture.

Data are presented as the means ± standard deviation if available.

Complications

Most studies stated the manner in which they assessed complications[8,20-23,25,29,33,36]; however, not all were according to the same reporting standards (Supplementary Table 2, available in the online version of the article). Of the 638 patients who underwent the transradial access, complications occurred in 12 (1.9%). These complications (Table 3) comprised minor bleeding in 1 patient,[36] right hemispheric stroke in 1 patient,[22] and radial artery rupture in 2 patients.[9] Furthermore, 1 study[8] reported a case of distal embolization and a psoas hematoma. Six more major adverse events were reported during follow-up of 2 months: 1 myocardial ischemia, 2 deaths, 1 emergent angioplasty, and 2 amputations. All events occurred in patients with critical limb ischemia. Postintervention radial artery patency was assessed in 8 studies[8,9,20,23,25,28,29,33] comprising 405 patients. Of these, the radial artery was patent in 379 (93.6%) patients after the intervention.

Meta-analysis

Four studies[20-23] (3 retrospective cohort studies and 1 prospective matched cohort trial) involving 114 transradial and 208 transfemoral patients were included in the meta-analysis. The pooled study population was homogeneous for age, underlying disease, and clinical symptoms. Lesions were located in the iliac artery, aortic bifurcation, SFA, CFA, or popliteal artery (Table 1).

The primary outcome, procedure success, was equal between access methods (OR 5.0, 95% CI 0.49 to 50.83, p=0.17; Figure 2A) for the 3 studies reporting this outcome (n=134).[20-22] It was not possible to calculate the statistical heterogeneity because of insufficient data. Transradial access showed a significant reduced complication rate (OR 0.25, 95% CI 0.07 to 0.86, p=0.03; Figure 2B) compared with the transfemoral approach; the heterogeneity was low (I2=0%). Complications are described in Table 4.

Figure 2.

Forest plots of the (A) procedure success and (B) complications outcomes. CI, confidence interval, M-H, Mantel-Haenszel.

Table 4.

Access-Site Complications in the 4 Studies Comparing Transradial to Transfemoral Access.

	Trani 2009[22]	Staniloae 2010[21]	Cortese 2012[20]	Roy 2016[23]
Radial artery	(n=12)	(n=27)	(n=21)	(n=65)
Bleeding	0	0	0	0
Hematoma	0	0	0	0
Pseudoaneurysm	0	0	0	0
Radial artery occlusion	NR	NR	0	2
Femoral artery	(n=12)	(n=41)	(n=21)	(n=123)
TIMI minor bleeding	0	0	1	0
TIMI major bleeding	0	0	1	0
Hematoma	0	0	0	1
Pseudoaneurysm	0	0	0	6
AV fistula	0	0	0	1
VCD failure	0	0	0	8
Persistent bleeding requiring more compression	0	3	0	0

Abbreviations: AV, arteriovenous; NR, not reported; TIMI, thrombolysis in myocardial infarction bleeding criteria; VCD, vascular closure device.

None of the secondary outcomes showed a significant advantage for one technique over the other: LOS (MD 0.24 days, 95% CI −0.52 to 0.04, p=0.09; I2=0%), fluoroscopy time (MD 2.47 minutes, 95% CI −7.10 to 2.16, p=0.08; I2=60%), procedure time (MD 4.20 minutes, 95% CI −11.74 to 3.35, p=0.28; I2=0%), and contrast volume (MD 7.24 mL, 95% CL −59.45 to 44.97, p=0.79; I2=76%).

Discussion

In percutaneous coronary interventions and coronary angiography, the radial artery has become the most commonly used access vessel. Evidence from the included studies in this review and meta-analysis suggests that the transradial access is feasible and possibly even safer for infra-aortic interventions because of the high procedure success and the significantly reduced risk of developing complications. The transradial approach is especially useful in the particular subset of patients in whom groin access is impeded by morbid obesity, occluded CFAs, prosthetic grafts, or severe iliac tortuosity.[28,37]

Limited evidence from the current meta-analysis showed no significant difference in procedure success between the access strategies. Only 1 study reported a significantly higher success rate for interventions performed via the femoral artery. However, their transradial group had significantly more occlusive lesions treated than in the transfemoral group, which may have influenced their results.

There are several reasons in favor of the transradial access, most notably decreased major access-site complications (eg, bleeding, hematoma, or pseudoaneurysm).[38] This random-effects meta-analysis substantiated a significant reduction in complications in patients who underwent transradial access (1.9%). The patients suffered fewer complications such as minor bleeding, myocardial infarction, embolic events, pseudoaneurysm, VCD failure, and hematoma. On the contrary, in transfemoral interventions, the reported incidences of access-site complications vary between 5% and 23% for hematoma, 0.5% and 9% for pseudoaneurysm, 0.2% to 2.1% for AV fistula, 0.8% to 20% for arterial occlusion, and <0.1% to 20% for infection.[39] These findings are consistent with a meta-analysis by Jolly et al,[40] which reported the risk of major bleeding or access-site bleeding to be 73% less with the transradial access in coronary interventions in comparison to the transfemoral route. The randomized controlled RIVAL trial[38] found a significantly increased risk of complications in the transfemoral access compared with the transradial in coronary angiography and interventions. Specifically, the risk of major bleedings, death, myocardial infarction, stroke, and major vascular complications was elevated in non-bypass procedures. Moreover, increased risks of large hematoma, pseudoaneurysm, and AV fistula was reported for the transfemoral access.

The most common complication of the transradial access in our review was radial artery occlusion. Unfortunately, postintervention radial artery occlusion was assessed in only 8 studies[8,9,20,23,25,28,29,33] comprising 405 patients, with a 6.4% incidence. In their meta-analysis, Rashid et al[41] focused on radial artery occlusion in transradial coronary interventions, concluding that radial artery occlusion was a common complication of transradial access. They reported a prevalence of 7.7% during the first 24 hours and 5.5% after 1 month. Furthermore, they reported that an increased intraprocedural dose of heparin (5000 units) was the most effective measure for the prevention of radial artery occlusion. A compression time of 15 minutes also seemed to preserve the patency of the radial artery.[41] In the 638 patients in our systematic review just 2 radial artery ruptures were disclosed. Furthermore, no hematoma, wound infection, or other access-related complications were reported.

Another advantage of transradial access is that a patient with a transfemoral access (depending on institution) is normally kept immobilized for 6 hours postprocedure, whereas in the transradial access this immobility is not necessary.[42] Our meta-analysis found a nonsignificant reduction of 0.24 days in LOS in comparison to the femoral access. The 1 article[21] that could not be used in the meta-analysis of this outcome measure found a significant reduction in the LOS (14.4 vs 20.9 hours, p=0.003) in the transradial access group. The mean time to discharge of all studies reviewed was 2.26 days. Taking all this into account, available data imply that the decreased LOS documented after transradial access in coronary interventions may be assumed for infra-aortic interventions as well.

In our review, the frequency of choosing the left or the right hand for the intervention was almost equal. The benefit of left radial artery access is the shorter distance to the descending aorta and the fact that the aortic arch does not have to be crossed. Some studies suggest that the stroke risk is lower in left-sided access because the catheters and wires do not have to cross the brachiocephalic trunk.[6] Moreover, the left subclavian artery often provides a direct route for catheter or sheath access to the descending aorta without the need for additional guiding catheters due to its natural curve into the aorta. However, other studies suggest that it is more comfortable for the interventionist to approach the patient via the right arm.[43] Another study by Lorenzoni et al[33] suggested positioning the patient upside down on the angiographic table with the left arm abducted wide. This positioning has the advantage that the flat panel is distant to the operator and can possibly be associated with less radiation exposure for the operator. One study compared left and right radial access and found no difference in procedure success.[23]

Three studies assessed the influence of the learning curve with opposing results. While Staniloae et al[21] stated that climbing the learning curve resulted in a shortening of the procedure time but not in improved procedure success rates, Coscas et al[9] and Ruzsa et al[8] found no statistical significant improvement of any outcome evaluating the effect of the learning curve.

Converting to femoral artery access due to failure to access the radial artery was seen in 9.5% of all patients who underwent a radial access intervention. The RIVAL[38] study reported an 8% rate of conversions in low-volume centers and 4.4% in high-volume centers. Challenging anatomy can be a reason to move to the femoral artery. Another reason could be the lack of sufficient and adequate instruments to reach peripheral lesions. Treatment failure due to inability to cross more distally located occlusive lesions was reported in several studies.[9,21,32,35] An explanation for this might perhaps be the meager pushablity from the transradial access.

Another issue that has to be mentioned for transradial access is the possibility that devices can be too short to reach the lesion in very tall patients.[28,33] Because radial access is a new and uncommon technique to treat lesions in the lower limb, current catheters, angioplasty balloons, and stent delivery systems may still limit the applicability of the access for all patients and lesions.[9]

Limitations

The biggest limitation of this study is the lack of any randomized controlled trials; rather, most of the studies included in this meta-analysis were cohort studies, which have a higher risk of publication bias than with randomized controlled trials. Another limitation of this study is the relatively small number of patients included. Furthermore, the studies included in the meta-analysis showed some heterogeneity. Among these studies patient characteristics concerning the body mass index, diabetes, and dyslipidemia differed. Symptomatology of peripheral artery disease according to the Fontaine or Rutherford classification was the same in all studies.

Most of the treated lesions were located in the iliac artery, but the studies performed by Trani et al[22,35] focused on lesions of the superficial femoral artery. The study conducted by Roy et al[23] included more occlusive lesions than the other studies did. The definitions of access complications were not the same among the studies, but the criterion for procedure success was. All of the above influences the external validity of our findings.

It is clearly necessary to perform randomized controlled trials in the near future to compare the transradial and transfemoral routes in the treatment of peripheral artery disease similar to those found in the coronary literature.

Conclusion

The transradial access for peripheral endovascular revascularization is a feasible and safe alternative to the conventional transfemoral route with potentially lower complication rates. Randomized controlled trials assessing procedural success, safety as well as cost benefits, are required to further validate the use of the transradial access in lower limb interventions.

Click here for additional data file.

Supplemental material, 18-0085_Supplementary_Tables for Transradial Approach for Aortoiliac and Femoropopliteal Interventions: A Systematic Review and Meta-analysis by Max M. Meertens, Eugene Ng, Stanley E. K. Loh, Miny Samuel, Barend M. E. Mees and Andrew M. T. L. Choong in Journal of Endovascular Therapy