| Literature DB >> 30085 |
M Brunori, M Coletta, B Giardina, J Wyman.
Abstract
Oxygen binding by trout Hb IV has been investigated as a function of pH up to 10 atmospheres (1 MPa) of pure O2. The results bring out an extreme proton-oxygen linkage, which gives rise to a Root effect. They are discussed in relation to the function of the hemoglobin as an oxygen pump. The system is of special interest as providing a prototype of a macromolecule acting as a transducer by coupling two allosterically linked reactions.Entities:
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Year: 1978 PMID： 30085 PMCID： PMC336103 DOI： 10.1073/pnas.75.9.4310
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205