Literature DB >> 3008449

Regulation of collagen biosynthesis by ascorbic acid: a review.

S R Pinnell.   

Abstract

L-ascorbic acid is an essential cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes essential for collagen biosynthesis. In addition, L-ascorbic acid preferentially stimulates collagen synthesis in a manner which appears unrelated to the effect of L-ascorbic acid on hydroxylation reactions. This reaction is stereospecific and unrelated to intracellular degradation of collagen. The effect apparently occurs at a transcriptional or translational level, since L-ascorbic acid preferentially stimulates collagen-specific mRNA. In addition, it stimulates lysyl hydroxylase activity but inhibits prolyl hydroxylase activity in human skin fibroblasts in culture.

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Year:  1985        PMID： 3008449      PMCID： PMC2589959     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN： 0044-0086


  8 in total

1.  Serum stimulation of lysyl hydroxylase activity in cultured human skin fibroblasts.

Authors:  S Murad; A Sivarajah; S R Pinnell
Journal:  Connect Tissue Res       Date:  1985       Impact factor: 3.417

2.  Regulation of prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts by ascorbic acid.

Authors:  S Murad; A Sivarajah; S R Pinnell
Journal:  Biochem Biophys Res Commun       Date:  1981-08-14       Impact factor: 3.575

3.  Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis.

Authors:  R S Bienkowski
Journal:  J Cell Physiol       Date:  1984-10       Impact factor: 6.384

4.  Procollagen I synthesis in human skin fibroblasts: effect on culture conditions on biosynthesis.

Authors:  H Freiberger; D Grove; A Sivarajah; S R Pinnell
Journal:  J Invest Dermatol       Date:  1980-11       Impact factor: 8.551

5.  Regulation of collagen synthesis by ascorbic acid. Ascorbic acid increases type I procollagen mRNA.

Authors:  S Tajima; S R Pinnell
Journal:  Biochem Biophys Res Commun       Date:  1982-05-31       Impact factor: 3.575

6.  The role of ascorbic acid in the biosynthesis of collagen. I. Ascorbic acid requirement by embryonic chick tibia in tissue culture.

Authors:  J J Jeffrey; G R Martin
Journal:  Biochim Biophys Acta       Date:  1966-06-29

7.  Collagen synthesis in cultured human skin fibroblasts: effect of ascorbic acid and its analogs.

Authors:  S Murad; S Tajima; G R Johnson; S Sivarajah; S R Pinnell
Journal:  J Invest Dermatol       Date:  1983-08       Impact factor: 8.551

8.  Regulation of collagen synthesis by ascorbic acid.

Authors:  S Murad; D Grove; K A Lindberg; G Reynolds; A Sivarajah; S R Pinnell
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205
  8 in total
  31 in total

1.  Tissue engineering of tumor stromal microenvironment with application to cancer cell invasion.

Authors:  Yi-Zhen Ng; Andrew P South
Journal:  J Vis Exp       Date:  2014-03-18       Impact factor: 1.355

2.  Aortic wall damage in mice unable to synthesize ascorbic acid.

Authors:  N Maeda; H Hagihara; Y Nakata; S Hiller; J Wilder; R Reddick
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

Review 3.  Vitamin and trace element deficiencies in the pediatric dialysis patient.

Authors:  Lyndsay A Harshman; Kathy Lee-Son; Jennifer G Jetton
Journal:  Pediatr Nephrol       Date:  2017-07-27       Impact factor: 3.714

4.  Polymer fiber-based models of connective tissue repair and healing.

Authors:  Nancy M Lee; Cevat Erisken; Thomas Iskratsch; Michael Sheetz; William N Levine; Helen H Lu
Journal:  Biomaterials       Date:  2016-10-12       Impact factor: 12.479

5.  Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice.

Authors:  John Cha; Aleksandra Niedzwiecki; Matthias Rath
Journal:  Am J Cardiovasc Dis       Date:  2015-03-20

6.  In vivo formation of bone and haematopoietic territories by transplanted human bone marrow stromal cells generated in medium with and without osteogenic supplements.

Authors:  Sergei A Kuznetsov; Mahesh H Mankani; Pamela Gehron Robey
Journal:  J Tissue Eng Regen Med       Date:  2011-11-03       Impact factor: 3.963

7.  Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy.

Authors:  Chung-Wei Lee; Xiang-Dong Wang; Kuo-Liong Chien; Zhongming Ge; Barry H Rickman; Arlin B Rogers; Andrea Varro; Mark T Whary; Timothy C Wang; James G Fox
Journal:  Int J Cancer       Date:  2008-03-01       Impact factor: 7.396

Review 8.  Bone quality: the determinants of bone strength and fragility.

Authors:  Hélder Fonseca; Daniel Moreira-Gonçalves; Hans-Joachim Appell Coriolano; José Alberto Duarte
Journal:  Sports Med       Date:  2014-01       Impact factor: 11.136

9.  Inhibition of collagen synthesis by select calcium and sodium channel blockers can be mitigated by ascorbic acid and ascorbyl palmitate.

Authors:  Vadim Ivanov; Svetlana Ivanova; Tatiana Kalinovsky; Aleksandra Niedzwiecki; Matthias Rath
Journal:  Am J Cardiovasc Dis       Date:  2016-05-18

10.  Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2.

Authors:  Rutger A F Gjaltema; Miesje M van der Stoel; Miriam Boersema; Ruud A Bank
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-13       Impact factor: 11.205
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