Asma H Almaghrebi 1 Show Affiliations »
Abstract
BACKGROUND: The clozapine-derivative quetiapine has been shown in some cases to cause leukopenia and neutropenia. CASE PRESENTATION: We reported on a case of a young female diagnosed with treatment-resistant schizophrenia. After failed trials of three antipsychotic medications and despite a history of quetiapineinduced leukopenia, clozapine treatment was introduced due to the severity of the patient's symptoms, the limited effective treatment options, and a lack of guidelines on this issue. RESULT: Over a ten-week period of clozapine treatment at 700 mg per day, the patient developed agranulocytosis. Her white blood cell count sharply dropped to 1.6 × 109 L, and her neutrophils decreased to 0.1 × 109 L. There had been no similar reaction to her previous medications (carbamazepine, risperidone, and haloperidol). CONCLUSION: The safety of clozapine in a patient who has previously experienced leukopenia and neutropenia with quetiapine requires further investigation. Increased attention should be paid to such cases. Careful monitoring and slow titration are advisable. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: The clozapine -derivative quetiapine has been shown in some cases to cause leukopenia and neutropenia . CASE PRESENTATION: We reported on a case of a young female diagnosed with treatment-resistant schizophrenia . After failed trials of three antipsychotic medications and despite a history of quetiapineinduced leukopenia , clozapine treatment was introduced due to the severity of the patient 's symptoms, the limited effective treatment options, and a lack of guidelines on this issue. RESULT: Over a ten-week period of clozapine treatment at 700 mg per day, the patient developed agranulocytosis . Her white blood cell count sharply dropped to 1.6 × 109 L, and her neutrophils decreased to 0.1 × 109 L. There had been no similar reaction to her previous medications (carbamazepine , risperidone , and haloperidol ). CONCLUSION: The safety of clozapine in a patient who has previously experienced leukopenia and neutropenia with quetiapine requires further investigation. Increased attention should be paid to such cases. Careful monitoring and slow titration are advisable. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Disease
Species
Keywords:
Clozapine; agranulocytosis; leukopenia; neutropenia; quetiapine; schizophrenia.
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Year: 2019
PMID： 30084338 DOI： 10.2174/1574886313666180807094654
Source DB: PubMed Journal: Curr Drug Saf ISSN： 1574-8863