| Literature DB >> 30084247 |
Xuesong Wu1,2, Faben A Cruz1, Alexander Lu1, Vy M Dong1.
Abstract
We report a Rh-catalyst for accessing olefins from primary alcohols by a C-C bond cleavage that results in dehomologation. This functional group interconversion proceeds by an oxidation-dehydroformylation enabled by N, N-dimethylacrylamide as a sacrificial acceptor of hydrogen gas. Alcohols with diverse functionality and structure undergo oxidative dehydroxymethylation to access the corresponding olefins. Our catalyst protocol enables a two-step semisynthesis of (+)-yohimbenone and dehomologation of feedstock olefins.Entities:
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Year: 2018 PMID： 30084247 PMCID： PMC6619493 DOI： 10.1021/jacs.8b06069
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419