Annélie S Anestin1,2, Sarah Lippé1,2, Philippe Robaey1,3,4, Laurence Bertout1, Simon Drouin1, Maja Krajinovic1,5, Bruno Michon6, Émélie Rondeau1, Mariia Samoilenko1,7, Caroline Laverdière1,5, Daniel Sinnett1,5, Serge Sultan1,2,5. 1. Sainte-Justine University Health Center (SJUHC), Montréal, Québec, Canada. 2. Department of Psychology, Université de Montréal, Montréal, Québec, Canada. 3. Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. 4. University of Ottawa, Ottawa, Ontario, Canada. 5. Department of Pediatrics, Université de Montréal, Montréal, Québec, Canada. 6. Quebec University Health Center (QUHC), Montréal, Québec, Canada. 7. Université du Québec à Montréal (UQAM), Montréal, Québec, Canada.
Abstract
BACKGROUND: Recent research has suggested that long-term pediatric cancer survivors were at risk of important physical and psychological morbidities. To date, we do not know to what extent functional health status contributes to psychological risk and which domains are most important. The aim of this study was to systematically explore which functional domain could explain anxiety, depression, and distress symptoms. PROCEDURE: We used data available for 105 adolescents and 182 adults successfully treated for childhood acute lymphoblastic leukemia at two Canadian sites part of the PETALE cohort. Participants were ≥5 years postdiagnosis, aged 22 ± 6 years, 52% female, and 49% acute lymphoblastic leukemia high-risk status. The contribution of health functional status (15D/16D questionnaires) to self-reported anxiety, depression, and distress (Beck scales and distress thermometer) was evaluated using adjusted logistic regression models. RESULTS: Prevalence rates found for mild-severe anxiety, depression, and distress were 14%, 21%, and 30% among adolescents and 27%, 20%, and 19% among adults. Frequent health domains associated with psychological risk were sleeping and breathing in adolescents, and vitality/fatigue, discomfort/symptoms, mental function, and sleeping in adults. Mental function was systematically associated with psychological risk across age groups (median OR = 10.00, 95% CI 3.01-33.71). Exploratory mediation bootstrapping analyses suggested that the effect on psychological risk of overall health status and mental function problems was partly explained by social/work/school functioning. CONCLUSION: The results identified important functional health domains that could be targeted for interventions preventing psychological risk: vitality/fatigue, discomfort/symptoms, sleeping, and mental function issues. Health domains probably affect mood partly by limiting social/work/school functioning.
BACKGROUND: Recent research has suggested that long-term pediatric cancer survivors were at risk of important physical and psychological morbidities. To date, we do not know to what extent functional health status contributes to psychological risk and which domains are most important. The aim of this study was to systematically explore which functional domain could explain anxiety, depression, and distress symptoms. PROCEDURE: We used data available for 105 adolescents and 182 adults successfully treated for childhood acute lymphoblastic leukemia at two Canadian sites part of the PETALE cohort. Participants were ≥5 years postdiagnosis, aged 22 ± 6 years, 52% female, and 49% acute lymphoblastic leukemia high-risk status. The contribution of health functional status (15D/16D questionnaires) to self-reported anxiety, depression, and distress (Beck scales and distress thermometer) was evaluated using adjusted logistic regression models. RESULTS: Prevalence rates found for mild-severe anxiety, depression, and distress were 14%, 21%, and 30% among adolescents and 27%, 20%, and 19% among adults. Frequent health domains associated with psychological risk were sleeping and breathing in adolescents, and vitality/fatigue, discomfort/symptoms, mental function, and sleeping in adults. Mental function was systematically associated with psychological risk across age groups (median OR = 10.00, 95% CI 3.01-33.71). Exploratory mediation bootstrapping analyses suggested that the effect on psychological risk of overall health status and mental function problems was partly explained by social/work/school functioning. CONCLUSION: The results identified important functional health domains that could be targeted for interventions preventing psychological risk: vitality/fatigue, discomfort/symptoms, sleeping, and mental function issues. Health domains probably affect mood partly by limiting social/work/school functioning.
Authors: Liv Andrés-Jensen; Mette Tiedemann Skipper; Kristian Mielke Christensen; Pia Hedegaard Johnsen; Katrine Aagaard Myhr; Martin Kaj Fridh; Kathrine Grell; A M L Pedersen; Sune Leisgaard Mørck Rubak; Martin Ballegaard; Arne Hørlyck; Rikke Beck Jensen; Trine-Lise Lambine; Kim Gjerum Nielsen; Ruta Tuckuviene; Peder Skov Wehner; Birgitte Klug Albertsen; Kjeld Schmiegelow; Thomas Leth Frandsen Journal: BMJ Open Date: 2021-02-09 Impact factor: 2.692
Authors: Liwen Peng; Lok Sum Yang; Perri Yam; Chun Sing Lam; Agnes Sui-Yin Chan; Chi Kong Li; Yin Ting Cheung Journal: Front Oncol Date: 2021-04-20 Impact factor: 6.244
Authors: Émélie Rondeau; Leandra Desjardins; Caroline Laverdière; Daniel Sinnett; Élie Haddad; Serge Sultan Journal: Health Psychol Behav Med Date: 2021-07-06