Rai Singh1, Sunita Sharma2, Sukhwinder Kaur2, Bikash Medhi3, Amita Trehan4, Sunil Kumar Bijarania5. 1. Department of Public Health Nursing, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. raisthory0777@gmail.com. 2. National Institute of Nursing Education, Postgraduate Institute of Medical Education and Research, Chandigarh, India. 3. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. 4. Hematology/Oncology Unit, Department of Pediatrics, Advance Pediatric Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India. 5. Department of Neonatology Nursing, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract
OBJECTIVE: To evaluate the effectiveness of topical application of honey on Oral Mucositis (OM) associated with chemotherapy. METHODS: An observational blind study is performed upon a sample of 100 children receiving chemotherapy who developed oral mucositis. All children are divided into two groups (control and experimental) who received different regimens. Both groups received routine practice of analgesic and antiseptic gel application whereas children in experimental group also received the topical application of honey on oral mucosa for the management of OM. All children are monitored from the day they developed oral mucositis until the subsidence of signs and symptoms of oral mucositis. The severity of OM was assessed with WHO-STC (Stomatitis Toxicity Criteria) scale by a observer blind. RESULTS: There was statistically significant difference in reduction of severity of OM in both groups of children (p < 0.01). The duration of management of OM was significantly small in the experimental group (median 4 d, IQR: 4-6 d) as compared to the control group (median 6 d, IQR: 6-8 d) (p < 0.01). CONCLUSIONS: The topical application of honey on oral mucosa was effective in reducing the severity and duration of management of chemotherapy induced oral mucositis (CIOM; p < 0.05) and that means honey is a good quality product with rich nutritious value and would be a pleasant, simple and cost-effective modality for the management of oral mucositis associated with chemotherapy.
RCT Entities:
OBJECTIVE: To evaluate the effectiveness of topical application of honey on Oral Mucositis (OM) associated with chemotherapy. METHODS: An observational blind study is performed upon a sample of 100 children receiving chemotherapy who developed oral mucositis. All children are divided into two groups (control and experimental) who received different regimens. Both groups received routine practice of analgesic and antiseptic gel application whereas children in experimental group also received the topical application of honey on oral mucosa for the management of OM. All children are monitored from the day they developed oral mucositis until the subsidence of signs and symptoms of oral mucositis. The severity of OM was assessed with WHO-STC (Stomatitis Toxicity Criteria) scale by a observer blind. RESULTS: There was statistically significant difference in reduction of severity of OM in both groups of children (p < 0.01). The duration of management of OM was significantly small in the experimental group (median 4 d, IQR: 4-6 d) as compared to the control group (median 6 d, IQR: 6-8 d) (p < 0.01). CONCLUSIONS: The topical application of honey on oral mucosa was effective in reducing the severity and duration of management of chemotherapy induced oral mucositis (CIOM; p < 0.05) and that means honey is a good quality product with rich nutritious value and would be a pleasant, simple and cost-effective modality for the management of oral mucositis associated with chemotherapy.