| Literature DB >> 30083891 |
Shengxiang Liang1,2,3, Xiaofeng Jiang4, Qingqing Zhang3, Shaofeng Duan2,5, Tianhao Zhang2,5, Qi Huang2,5, Xi Sun1,2, Hua Liu2,5, Jie Dong1, Weilin Liu3, Jing Tao3, Shujun Zhao6, Binbin Nie7,8,9, Lidian Chen3, Baoci Shan2,5,10.
Abstract
Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion (MCAO) at the acute stage using 18F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO. Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together, the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research.Entities:
Keywords: Acute; FDG PET; Ischemic stroke; Metabolic connectivity
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Year: 2018 PMID： 30083891 PMCID： PMC6129253 DOI： 10.1007/s12264-018-0266-y
Source DB: PubMed Journal: Neurosci Bull ISSN： 1995-8218 Impact factor: 5.203