| Literature DB >> 30082898 |
Fazhan Shi1,2,3, Fei Kong1,2,3, Pengju Zhao1,3, Xiaojun Zhang4, Ming Chen1,3, Sanyou Chen1,3, Qi Zhang1,3, Mengqi Wang1,3, Xiangyu Ye1,2,3, Zhecheng Wang1,3, Zhuoyang Qin1,3, Xing Rong1,2,3, Jihu Su1,2,3, Pengfei Wang1,2,3, Peter Z Qin5, Jiangfeng Du6,7,8.
Abstract
Magnetic resonance spectroscopy of single biomolecules under near-physiological conditions could substantially advance understanding of their biological function, but this approach remains very challenging. Here we used nitrogen-vacancy centers in diamonds to detect electron spin resonance spectra of individual, tethered DNA duplexes labeled with a nitroxide spin label in aqueous buffer solutions at ambient temperatures. This work paves the way for magnetic resonance studies on single biomolecules and their intermolecular interactions in native-like environments.Entities:
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Year: 2018 PMID： 30082898 DOI： 10.1038/s41592-018-0084-1
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547