Tony K T Lam1,2,3,4, David Z I Cherney5,6,7,8,9. 1. Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada. 2. Department of Physiology, University of Toronto, Toronto, Ontario, Canada. 3. Department of Medicine, University of Toronto, Toronto, Ontario, Canada. 4. Banting and Best Diabetes Centre, Toronto, Ontario, Canada. 5. Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada. david.cherney@uhn.ca. 6. Department of Physiology, University of Toronto, Toronto, Ontario, Canada. david.cherney@uhn.ca. 7. Department of Medicine, University of Toronto, Toronto, Ontario, Canada. david.cherney@uhn.ca. 8. Banting and Best Diabetes Centre, Toronto, Ontario, Canada. david.cherney@uhn.ca. 9. Department of Medicine, Division of Nephrology, University Health Network, Toronto, Ontario, Canada. david.cherney@uhn.ca.