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Literature DB >> 30082288

First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate Harboring a TR46 Y121F T289A Mutation in South America.

Guillermina Isla¹, Florencia Leonardelli^2,3, Iris N Tiraboschi⁴, Nicolás Refojo¹, Alejandra Hevia¹, Walter Vivot¹, Wanda Szusz¹, Susana B Córdoba¹, Guillermo García-Effron^5,3.

Abstract

One of the most recently described Aspergillus fumigatusCYP51A-mediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.

Entities: Chemical Mutation Species

Keywords: Aspergillus fumigatus; CYP51A; South America; TR46; TR46 Y121F T289A mutation; azole; resistance

Mesh：

Substances：

Year: 2018 PMID： 30082288 PMCID： PMC6153829 DOI： 10.1128/AAC.00872-18

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

25 in total

1. Emergence of TR46/Y121F/T289A in an Aspergillus fumigatus isolate from a Chinese patient.

Authors: Yong Chen; Huan Wang; Zhongyi Lu; Peng Li; Qing Zhang; Tianye Jia; Jingya Zhao; Shuguang Tian; Xuelin Han; Fangyan Chen; Changjian Zhang; Xiaodong Jia; Liuyu Huang; Fen Qu; Li Han
Journal: Antimicrob Agents Chemother Date: 2015-08-17 Impact factor: 5.191

2. A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

Authors: E Mellado; G Garcia-Effron; L Alcázar-Fuoli; W J G Melchers; P E Verweij; M Cuenca-Estrella; J L Rodríguez-Tudela
Journal: Antimicrob Agents Chemother Date: 2007-03-19 Impact factor: 5.191

3. Genotype-phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus.

Authors: Eveline Snelders; Simone M T Camps; Anna Karawajczyk; Antonius J M M Rijs; Jan Zoll; Paul E Verweij; Willem J G Melchers
Journal: Fungal Genet Biol Date: 2015-06-16 Impact factor: 3.495

4. Isolation of azole-resistant Aspergillus fumigatus from the environment in the south-eastern USA.

Authors: Steven F Hurst; Elizabeth L Berkow; Katherine L Stevenson; Anastasia P Litvintseva; Shawn R Lockhart
Journal: J Antimicrob Chemother Date: 2017-09-01 Impact factor: 5.790

5. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.

Authors: A J Ullmann; J M Aguado; S Arikan-Akdagli; D W Denning; A H Groll; K Lagrou; C Lass-Flörl; R E Lewis; P Munoz; P E Verweij; A Warris; F Ader; M Akova; M C Arendrup; R A Barnes; C Beigelman-Aubry; S Blot; E Bouza; R J M Brüggemann; D Buchheidt; J Cadranel; E Castagnola; A Chakrabarti; M Cuenca-Estrella; G Dimopoulos; J Fortun; J-P Gangneux; J Garbino; W J Heinz; R Herbrecht; C P Heussel; C C Kibbler; N Klimko; B J Kullberg; C Lange; T Lehrnbecher; J Löffler; O Lortholary; J Maertens; O Marchetti; J F Meis; L Pagano; P Ribaud; M Richardson; E Roilides; M Ruhnke; M Sanguinetti; D C Sheppard; J Sinkó; A Skiada; M J G T Vehreschild; C Viscoli; O A Cornely
Journal: Clin Microbiol Infect Date: 2018-03-12 Impact factor: 8.067

6. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.

Authors: Ben De Pauw; Thomas J Walsh; J Peter Donnelly; David A Stevens; John E Edwards; Thierry Calandra; Peter G Pappas; Johan Maertens; Olivier Lortholary; Carol A Kauffman; David W Denning; Thomas F Patterson; Georg Maschmeyer; Jacques Bille; William E Dismukes; Raoul Herbrecht; William W Hope; Christopher C Kibbler; Bart Jan Kullberg; Kieren A Marr; Patricia Muñoz; Frank C Odds; John R Perfect; Angela Restrepo; Markus Ruhnke; Brahm H Segal; Jack D Sobel; Tania C Sorrell; Claudio Viscoli; John R Wingard; Theoklis Zaoutis; John E Bennett
Journal: Clin Infect Dis Date: 2008-06-15 Impact factor: 9.079

7. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry.

Authors: D Neofytos; D Horn; E Anaissie; W Steinbach; A Olyaei; J Fishman; M Pfaller; C Chang; K Webster; K Marr
Journal: Clin Infect Dis Date: 2009-02-01 Impact factor: 9.079

8. Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles.

Authors: Jan W M van der Linden; Simone M T Camps; Greetje A Kampinga; Jan P A Arends; Yvette J Debets-Ossenkopp; Pieter J A Haas; Bart J A Rijnders; Ed J Kuijper; Frank H van Tiel; János Varga; Anna Karawajczyk; J Zoll; Willem J G Melchers; Paul E Verweij
Journal: Clin Infect Dis Date: 2013-05-10 Impact factor: 9.079

9. Azole-resistant Aspergillus fumigatus harboring TR₃₄/L98H, TR₄₆/Y121F/T289A and TR₅₃ mutations related to flower fields in Colombia.

Authors: Carlos Alvarez-Moreno; Rose-Anne Lavergne; Ferry Hagen; Florent Morio; Jacques F Meis; Patrice Le Pape
Journal: Sci Rep Date: 2017-03-30 Impact factor: 4.379

10. Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

Authors: Susan J Howard; Dasa Cerar; Michael J Anderson; Ahmed Albarrag; Matthew C Fisher; Alessandro C Pasqualotto; Michel Laverdiere; Maiken C Arendrup; David S Perlin; David W Denning
Journal: Emerg Infect Dis Date: 2009-07 Impact factor: 6.883

7 in total

1. Aspergillus fumigatus Clinical Isolates Carrying CYP51A with TR34/L98H/S297T/F495I Substitutions Detected after Four-Year Retrospective Azole Resistance Screening in Brazil.

Authors: Laís Pontes; Caio Augusto Gualtieri Beraquet; Teppei Arai; Guilherme Leite Pigolli; Luzia Lyra; Akira Watanabe; Maria Luiza Moretti; Angélica Zaninelli Schreiber
Journal: Antimicrob Agents Chemother Date: 2020-02-21 Impact factor: 5.191

Review 2. Aspergillus fumigatus and aspergillosis: From basics to clinics.

Authors: A Arastehfar; A Carvalho; J Houbraken; L Lombardi; R Garcia-Rubio; J D Jenks; O Rivero-Menendez; R Aljohani; I D Jacobsen; J Berman; N Osherov; M T Hedayati; M Ilkit; D James-Armstrong; T Gabaldón; J Meletiadis; M Kostrzewa; W Pan; C Lass-Flörl; D S Perlin; M Hoenigl
Journal: Stud Mycol Date: 2021-05-10 Impact factor: 16.097