Dahai Yu1, Wei Yang2, Tao Chen3, Yamei Cai4, Zhanzheng Zhao5, David Simmons6. 1. Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China; Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele ST5 5BG, UK. 2. Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China; School of Medicine, Washington University in St. Louis, 660 S Euclid Ave, St. Louis, MO 63110, United States. 3. Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China; Tropical Clinical Trials Unit, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. 4. Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. 5. Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Electronic address: zhanzhengzhao@zzu.edu.cn. 6. Macarthur Clinical School, School of Medicine, Western Sydney University, Locked Bag 1797, Campbelltown, Sydney, NSW 2751, Australia. Electronic address: dsworkster@gmail.com.
Abstract
OBJECTIVE: We aimed to compare the association of hypertriglyceridemic-waist (HTGW), with glycaemia, liver and renal function between a Chinese and an Australian population using 3 HTGW definitions. METHODS: 1454 Australian and 5824 Chinese adults, from randomly selected households provided clinical history, glucose, lipids, anthropometric, and blood pressure measurements. Liver and renal functions were assessed using alanine aminotransferase and estimated Glomerular Filtration Rate respectively. The impact of interaction between HTGW and glucose on the liver and renal functions were measured by General Linear Model. Logistic regression was used to estimate the association between this interaction and abnormal liver and renal function. RESULTS: HTGW was associated with abnormal liver and renal function in both Chinese and Australian populations using all 3 HTGW definitions. The highest sensitivity (93 (95% confidence interval: 87, 97) %) and specificity (81 (80, 84) %) were observed for abnormal renal function in the Australian population. The probability of having abnormal liver or renal function increased with glucose in the presence of HTGW phenotype only in the Australian population. Similar findings were revealed in people without type 2 diabetes. CONCLUSIONS: In both Chinese and Australian populations, HTGW is associated with abnormal liver and renal function using any of the 3 definitions. HTGW is a potential tool to identify high-risk individuals with impaired renal function especially in the Australian population. HTGW interacted with the fasting glucose in its association with impaired liver and renal function only in the Australian population, suggesting different underlying interactions between environmental and genetic backgrounds.
OBJECTIVE: We aimed to compare the association of hypertriglyceridemic-waist (HTGW), with glycaemia, liver and renal function between a Chinese and an Australian population using 3 HTGW definitions. METHODS: 1454 Australian and 5824 Chinese adults, from randomly selected households provided clinical history, glucose, lipids, anthropometric, and blood pressure measurements. Liver and renal functions were assessed using alanine aminotransferase and estimated Glomerular Filtration Rate respectively. The impact of interaction between HTGW and glucose on the liver and renal functions were measured by General Linear Model. Logistic regression was used to estimate the association between this interaction and abnormal liver and renal function. RESULTS: HTGW was associated with abnormal liver and renal function in both Chinese and Australian populations using all 3 HTGW definitions. The highest sensitivity (93 (95% confidence interval: 87, 97) %) and specificity (81 (80, 84) %) were observed for abnormal renal function in the Australian population. The probability of having abnormal liver or renal function increased with glucose in the presence of HTGW phenotype only in the Australian population. Similar findings were revealed in people without type 2 diabetes. CONCLUSIONS: In both Chinese and Australian populations, HTGW is associated with abnormal liver and renal function using any of the 3 definitions. HTGW is a potential tool to identify high-risk individuals with impaired renal function especially in the Australian population. HTGW interacted with the fasting glucose in its association with impaired liver and renal function only in the Australian population, suggesting different underlying interactions between environmental and genetic backgrounds.