The influence of extreme cold events on mortality in the United States.

Many studies have analyzed the effects of extreme heat on human mortality, however fewer studies have focused on the effects of cold related mortality due to the complicated nature of the lagged response. This study utilized a Distributed Lag Non-Linear Model with a 30-day lag to determine the cumulative effects of extreme cold events (ECEs) on mortality across 32 cities in the United States for the period of 1975-2010. ECEs were divided into specific categories based on duration, magnitude, and timing of occurrence. Mortality was divided into all-age mortality as well as mortality of individuals >64 years old. The findings suggest a strong relationship between a city's latitude as well as the timing of an ECE with mortality. Early season ECEs result in a much higher relative risk of increased mortality, particularly in cities with higher mean winter temperatures, while the RR of mortality of individuals >64 was consistently higher for each city. This study suggests early season ECEs should receive enhanced preparedness efforts as individuals may be particularly vulnerable when not acclimatized to extreme cold.