Literature DB >> 30080930

Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery.

Thinzar M Lwin1, Robert M Hoffman1,2, Michael Bouvet1,3.   

Abstract

Fluorescence-guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe evaluation and highlights the advantages of patient-derived orthotopic xenografts (PDOX) mouse models and genetic reporters to develop fluorescence-guided surgery.
© 2018 Wiley Periodicals, Inc.

Entities:  

Keywords:  fluorescence-guided surgery (FGS); genetic reporters; patient-derived orthotopic xenografts (PDOX); preclinical mouse models; surgical orthotopic implantation (SOI)

Mesh:

Substances:

Year:  2018        PMID: 30080930      PMCID: PMC6146062          DOI: 10.1002/jso.25150

Source DB:  PubMed          Journal:  J Surg Oncol        ISSN: 0022-4790            Impact factor:   3.454


  105 in total

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