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Literature DB >> 3007997

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.

P Besmer, J E Murphy, P C George, F H Qiu, P J Bergold, L Lederman, H W Snyder, D Brodeur, E E Zuckerman, W D Hardy.

Abstract

A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3007997 DOI： 10.1038/320415a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

156 in total

Review 1. Targeting KIT in melanoma: a paradigm of molecular medicine and targeted therapeutics.

Authors: Scott E Woodman; Michael A Davies
Journal: Biochem Pharmacol Date: 2010-05-08 Impact factor: 5.858

2. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

Authors: E J Huang; K H Nocka; J Buck; P Besmer
Journal: Mol Biol Cell Date: 1992-03 Impact factor: 4.138

3. Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase.

Authors: S Lev; D Givol; Y Yarden
Journal: Proc Natl Acad Sci U S A Date: 1992-01-15 Impact factor: 11.205

4. Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment.

Authors: M Krawczak; D N Cooper
Journal: Hum Genet Date: 1991-03 Impact factor: 4.132

5. Relationship between gene mutations and protein expressions of PDGFR α and C-kit in gastrointestinal stromal tumors.

Authors: Jun-Yi He; H X Tong; Y Zhang; J Y Wang; Y B Shao; J Zhu; Wei-Qi Lu
Journal: Int J Clin Exp Med Date: 2015-05-15

6. Inhibitory effect of 1 alpha,25-dihydroxyvitamin D3 on mast cell proliferation and A23187-induced histamine release, also accompanied by a decreased c-kit receptor.

Authors: N Toyota; H Sakai; H Takahashi; Y Hashimoto; H Iizuka
Journal: Arch Dermatol Res Date: 1996-10 Impact factor: 3.017

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.

Review 1. Targeting KIT in melanoma: a paradigm of molecular medicine and targeted therapeutics.

2. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

3. Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase.

4. Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment.

5. Relationship between gene mutations and protein expressions of PDGFR α and C-kit in gastrointestinal stromal tumors.

6. Inhibitory effect of 1 alpha,25-dihydroxyvitamin D3 on mast cell proliferation and A23187-induced histamine release, also accompanied by a decreased c-kit receptor.

7. c-kit (CD117) expression in human tumors and its prognostic value: an immunohistochemical analysis.

Review 8. Treatment for chronic myelogenous leukemia: the long road to imatinib.

9. Interspecies molecular chimeras of kit help define the binding site of the stem cell factor.

10. Delineation of functional determinants in the transforming protein of Fujinami sarcoma virus.