Literature DB >> 300780

Immunological studies of Aging. III. Cytokinetic basis for the impaired response of lymphocytes from aged humans to plant lectins.

B Inkeles, J B Innes, M M Kuntz, A S Kadish, M E Weksler.   

Abstract

The basis for the age-associated defect in the response of lymphocytes to plant lectins has been studied. Using three independent assays we have shown that the number of mitogen-responsive cells is markedly reduced in lymphocyte preparations from old persons. In addition, studies using colchicine bloock and thymidine pulse techniques have revealed a failure of mitogen-responsive cells from old persons to expand into a proliferating pool of lymphocytes as is observed when lymphocytes from young persons are cultured with phytohemagglutinin. Thus, the impaired response of lymphocytes from old persons to mitogens is attributable to a reduced number of mitogen responsive cells and their failure to undergo clonal expansion.

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Year:  1977        PMID： 300780      PMCID： PMC2180656          DOI： 10.1084/jem.145.5.1176

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  16 in total

1.  Lymphocyte responses to phytohaemagglutinin: age-related effects.

Authors:  L A Fernandez; J M MacSween; G R Langley
Journal:  Immunology       Date:  1976-10       Impact factor: 7.397

2.  The cell biology of human aging.

Authors:  L Hayflick
Journal:  N Engl J Med       Date:  1976-12-02       Impact factor: 91.245

3.  The sheep-cell rosette: test on human peripheral blood lymyphocytes: an analysis of some analysis of some variable factors in the technique.

Authors:  C M Steel; J Evans; M A Smith
Journal:  Br J Haematol       Date:  1974-10       Impact factor: 6.998

4.  Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.

Authors:  J F Bach; M Dardenne; J C Salomon
Journal:  Clin Exp Immunol       Date:  1973-06       Impact factor: 4.330

5.  Rosette-forming T cells in human peripheral blood at different ages.

Authors:  E D Carosella; K Mochanko; M Braun
Journal:  Cell Immunol       Date:  1974-05       Impact factor: 4.868

6.  Age-related variation in proportion of circulating T cells.

Authors:  M A Smith; J Evans; C M Steel
Journal:  Lancet       Date:  1974-10-19       Impact factor: 79.321

7.  Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans.

Authors:  H M Hallgren; C E Buckley; V A Gilbertsen; E J Yunis
Journal:  J Immunol       Date:  1973-10       Impact factor: 5.422

8.  Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.

Authors:  B S Foad; L E Adams; Y Yamauchi; A Litwin
Journal:  Clin Exp Immunol       Date:  1974-08       Impact factor: 4.330

9.  Impaired lymphocyte function in aged humans.

Authors:  M E Weksler; T H Hütteroth
Journal:  J Clin Invest       Date:  1974-01       Impact factor: 14.808

10.  Stimulated lymphocyte cultures: responder recruitment and cell cycle kinetics.

Authors:  H P Lohrmann; C M Graw; R G Graw
Journal:  J Exp Med       Date:  1974-05-01       Impact factor: 14.307
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  26 in total

1.  Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis.

Authors:  E Mariani; P Roda; A R Mariani; M Vitale; A Degrassi; S Papa; A Facchini
Journal:  Clin Exp Immunol       Date:  1990-09       Impact factor: 4.330

2.  Increased activity of oligo-2',5'-adenylate synthetase in Down's syndrome and epilepsy.

Authors:  N Fujii; K Oguma; M Fujii; R Fukatsu; N Takahata; M Kitabatake
Journal:  Clin Exp Immunol       Date:  1987-04       Impact factor: 4.330

3.  Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes.

Authors:  J E Nagel; R K Chopra; D C Powers; W H Adler
Journal:  Clin Exp Immunol       Date:  1989-02       Impact factor: 4.330

4.  Impaired nuclear responsiveness to cytoplasmic signals in lymphocytes from elderly humans with depressed proliferative responses.

Authors:  J K Gutowski; J B Innes; M E Weksler; S Cohen
Journal:  J Clin Invest       Date:  1986-07       Impact factor: 14.808

5.  Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70.

Authors:  J S Goodwin; R P Messner
Journal:  J Clin Invest       Date:  1979-08       Impact factor: 14.808

6.  Studies on the syngeneic mixed lymphocyte reaction. II. Decline in he syngeneic mixed lymphocyte reaction with age.

Authors:  J K Gutowski; M E Weksler
Journal:  Immunology       Date:  1982-08       Impact factor: 7.397

7.  Age-related impairment of the in vitro antibody response in the human.

Authors:  J F Delfraissy; P Galanaud; J Dormont; C Wallon
Journal:  Clin Exp Immunol       Date:  1980-01       Impact factor: 4.330

8.  Lymphocyte transformation induced by autologous cells. XI. The effect of age on the autologous mixed lymphocyte reaction.

Authors:  C E Moody; J B Innes; L Staiano-Coico; G S Incefy; H T Thaler; M E Weksler
Journal:  Immunology       Date:  1981-10       Impact factor: 7.397

9.  Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

Authors:  S Gillis; R Kozak; M Durante; M E Weksler
Journal:  J Clin Invest       Date:  1981-04       Impact factor: 14.808

10.  Age-related effects on the number of human lymphocytes in culture initially responding to an antigenic stimulus.

Authors:  P G Sohnle; C Collins-Lech; K E Huhta
Journal:  Clin Exp Immunol       Date:  1982-01       Impact factor: 4.330
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