Xi Cheng1, Jian Xu2, Mengmeng Gu3, Mengmeng Wang4, Bo Sun3, Zibao Li3, Guihua Ni5, Guiling Wang6, Zhiqiang Weng6, Yonghui Shi7, Zhizhong Zhang8, Xinfeng Liu9. 1. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing 210002, Jiangsu, China; Department of Geriatrics, The First Affiliation Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China. 2. Neurology Department, Wayne State University/Detroit Medical Center, Detroit, MI 48201, USA. 3. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing 210002, Jiangsu, China. 4. Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China. 5. Department of Neurology, Huai'an First People's Hospital, Huai'an, Jiangsu, China. 6. The Outpatient Department, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China. 7. Department of Clinical Laboratory, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. 8. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing 210002, Jiangsu, China; Department of Neurology, Jinling Hospital, Nanjing 210002, Jiangsu, China. Electronic address: zhizhongn@163.com. 9. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing 210002, Jiangsu, China; Department of Neurology, Jinling Hospital, Nanjing 210002, Jiangsu, China. Electronic address: xfliu2@vip.163.com.
Abstract
BACKGROUND AND PURPOSE: Genome-wide association studies discovered a novel correlation between chromosome 12q24 and ischemic stroke in European populations. This study aimed to determine whether two genetic variants (rs10744777 and rs886205) on chromosome 12q24 can modify the risk of ischemic stroke in Chinese population. METHODS: We recruited 1195 patients with ischemic stroke and 642 healthy Chinese individuals. The rs10744777 and rs886205 polymorphisms in aldehyde dehydrogenase2 (ALDH2) was genotyped and compared using multivariate logistic regression. RESULTS: The genotype of rs10744777 (CT/TT) was associated with risk of ischemic stroke in males (OR = 1.99, 95% CI = 1.15-3.42, P = 0.013). In contrast, no significant correlation was found in females. Haplotype analysis indicated that haplotype "TA" was associated with increased ischemic stroke risk (OR = 1.85, 95% CI = 1.10-3.12, P = 0.042). Further subtype analysis demonstrated that the rs10744777 (CT/TT) genotype was strongly associated with large artery atherosclerosis subtype in males (OR = 2.27, 95% CI = 1.30-3.95, P = 0.004). After three months follow-up, we found a poorer functional outcome of ischemic stroke associated with the rs886205 GA genotype (OR = 1.76, 95% CI 1.03-3.00, P = 0.057) in males. CONCLUSIONS: Genetic polymorphisms in ALDH2 modified ischemic stroke risk and outcome in Chinese males, but not in females.
BACKGROUND AND PURPOSE: Genome-wide association studies discovered a novel correlation between chromosome 12q24 and ischemic stroke in European populations. This study aimed to determine whether two genetic variants (rs10744777 and rs886205) on chromosome 12q24 can modify the risk of ischemic stroke in Chinese population. METHODS: We recruited 1195 patients with ischemic stroke and 642 healthy Chinese individuals. The rs10744777 and rs886205 polymorphisms in aldehyde dehydrogenase2 (ALDH2) was genotyped and compared using multivariate logistic regression. RESULTS: The genotype of rs10744777 (CT/TT) was associated with risk of ischemic stroke in males (OR = 1.99, 95% CI = 1.15-3.42, P = 0.013). In contrast, no significant correlation was found in females. Haplotype analysis indicated that haplotype "TA" was associated with increased ischemic stroke risk (OR = 1.85, 95% CI = 1.10-3.12, P = 0.042). Further subtype analysis demonstrated that the rs10744777 (CT/TT) genotype was strongly associated with large artery atherosclerosis subtype in males (OR = 2.27, 95% CI = 1.30-3.95, P = 0.004). After three months follow-up, we found a poorer functional outcome of ischemic stroke associated with the rs886205 GA genotype (OR = 1.76, 95% CI 1.03-3.00, P = 0.057) in males. CONCLUSIONS: Genetic polymorphisms in ALDH2 modified ischemic stroke risk and outcome in Chinese males, but not in females.