| Literature DB >> 3007715 |
J L Sullivan, F E Brewster, D B Brettler, A D Forsberg, S H Cheeseman, K S Byron, S M Baker, D L Willitts, R A Lew, P H Levine.
Abstract
The relationship between hemophiliac immunodeficiency and exposures to factor VIII concentrate, LAV/HTLV-III retrovirus, and infection with Epstein-Barr virus and cytomegalovirus was examined. Exposure to factor VIII concentrate was significantly correlated with decreased percentages of T helper/inducer cells, decreased T helper/suppressor cell ratios, and decreased proliferative responses to plant mitogens. LAV/HTLV-III seropositivity was the primary predictor of increased percentages of HLA-DR-bearing mononuclear cells and decreased proliferative responses to pokeweed mitogen. Epstein-Barr virus and cytomegalovirus infections acted in a synergistic manner with LAV/HTLV-III to produce immunoregulatory defects. Increased percentages of T suppressor cells and decreased delayed cutaneous hypersensitivity skin test responses were observed in LAV/HTLV-III seropositive hemophiliacs infected with Epstein-Barr or cytomegalovirus. We conclude that hemophiliacs receiving commercial factor VIII concentrate experience several stepwise incremental insults to the immune system: alloantigens in factor VIII concentrate, LAV/HTLV-III infections, and herpesvirus infections.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3007715 DOI： 10.1016/s0022-3476(86)80823-x
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406