| Literature DB >> 30076742 |
Ying Shen1,2, Xin Li1,2, Bin Zhao1,2, Yanru Xue1,2, Shenghang Wang1,2, Xin Chen1,2, Jiancheng Yang1,2, Huanhuan Lv1,2, Peng Shang2,3.
Abstract
Iron metabolism is crucial to hepatocellular carcinoma progression and is a key determinant of prognosis. Protein-protein interactions within the iron metabolism gene network were analyzed using the European Molecular Biology Laboratory's Search Tool for Recurring Instances of Neighbouring Genes/Proteins database. We obtained 423 liver hepatocellular carcinoma gene expression profiles from the Cancer Genome Atlas database. The expression and pathway enrichment of representative iron intake genes (TFRC and DMT1), utilization genes (FTH1, FTL, HIF1A, HMOX1, SLC25A37, and SLC25A38), and efflux genes (FLVCR1 and SLC40A1) was investigated in tumor and adjacent tissues. We determined the relationship between iron metabolism and the prognostic features of liver hepatocellular carcinoma. The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma. Our results provide novel insight into liver cancer therapy.Entities:
Keywords: TCGA; bioinformatics; hepatocellular carcinoma (HCC); iron metabolism; prognosis
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Year: 2018 PMID： 30076742 DOI： 10.1002/jcb.27184
Source DB: PubMed Journal: J Cell Biochem ISSN： 0730-2312 Impact factor: 4.429