W Klingler1, E Pfenninger2. 1. Anästhesie und Intensivmedizin, SRH Kliniken Landkreis Sigmaringen GmbH, Hohenzollernstraße 40, 72488, Sigmaringen, Deutschland. anaesthesie.sigmaringen@klksig.de. 2. Stabsstelle Katastrophenschutz, Universitätsklinikum Ulm, Oberer Eselsberg, 89081, Ulm, Deutschland. ernst.pfenninger@uni-ulm.de.
Abstract
BACKGROUND: According to the 2010 S3 Guidelines, analgosedation is an option for ventilated patients in intensive care units (ICU). Therefore, adverse effects of volatile anesthetics can occur in areas outside of surgical medical fields. OBJECTIVE: The aim is to inform ICU physicians about the clinical and legal challenges of a life-threatening pharmacogenetic reaction to inhalational anesthetics, malignant hyperthermia (MH). DISCUSSION: Consequences of an MH crisis for doctors, patients, and relatives regarding patient rights legislation, as well as insurance and employment issues with respect to the German Genetic Diagnostics Act are discussed.
BACKGROUND: According to the 2010 S3 Guidelines, analgosedation is an option for ventilated patients in intensive care units (ICU). Therefore, adverse effects of volatile anesthetics can occur in areas outside of surgical medical fields. OBJECTIVE: The aim is to inform ICU physicians about the clinical and legal challenges of a life-threatening pharmacogenetic reaction to inhalational anesthetics, malignant hyperthermia (MH). DISCUSSION: Consequences of an MH crisis for doctors, patients, and relatives regarding patient rights legislation, as well as insurance and employment issues with respect to the German Genetic Diagnostics Act are discussed.
Entities:
Keywords:
Dantrolene; General anesthesia; German Genetic Diagnostics Act; Malignant hyperthermia; Pharmacogenetics
Authors: T V McCarthy; J M Healy; J J Heffron; M Lehane; T Deufel; F Lehmann-Horn; M Farrall; K Johnson Journal: Nature Date: 1990-02-08 Impact factor: 49.962