Literature DB >> 3007540

Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.

J L Cruise, S Cotecchia, G Michalopoulos.   

Abstract

Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. This effect was maximal after 1 hr of incubation with NE and could be blocked by the presence of an alpha 1-specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction in EGF receptor number, without a significant change in receptor affinity.

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Year:  1986        PMID： 3007540     DOI： 10.1002/jcp.1041270106

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  9 in total

1.  Ethanolamine modulates the rate of rat hepatocyte proliferation in vitro and in vivo.

Authors:  H Sasaki; H Kume; A Nemoto; S Narisawa; N Takahashi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

2.  Alpha 1-adrenergic receptors in liver regeneration.

Authors:  J L Cruise
Journal:  Dig Dis Sci       Date:  1991-04       Impact factor: 3.199

3.  Stimulation of rat hepatocyte proliferation in vitro and in vivo by factors derived from the bovine small intestinal mucosa.

Authors:  H Sasaki; A Nemoto; H Kume; S Narisawa; N Takahashi
Journal:  In Vitro Cell Dev Biol Anim       Date:  1998-01       Impact factor: 2.416

4.  Extraction and partial purification of a hepatic stimulatory substance in rats, mice, and dogs.

Authors:  A Francavilla; P Ove; L Polimeno; M Coetzee; L Makowka; J Rose; D H Van Thiel; T E Starzl
Journal:  Cancer Res       Date:  1987-11-01       Impact factor: 12.701

5.  Regulation of surface expression of high-affinity receptors for epidermal growth factor (EGF) in hepatocytes by hormones, differentiating agents, and phorbol ester.

Authors:  I P Gladhaug; M Refsnes; T Christoffersen
Journal:  Dig Dis Sci       Date:  1992-02       Impact factor: 3.199

6.  Growth-regulatory effects of glucagon, insulin, and epidermal growth factor in cultured hepatocytes. Temporal aspects and evidence for bidirectional control by cyclic AMP.

Authors:  T E Sand; G H Thoresen; M Refsnes; T Christoffersen
Journal:  Dig Dis Sci       Date:  1992-01       Impact factor: 3.199

Review 7.  Transcriptional down-regulation of epidermal growth factor (EGF) receptors by nerve growth factor (NGF) in PC12 cells.

Authors:  Gadi Cohen; Keren Ettinger; Shimon Lecht; Peter I Lelkes; Philip Lazarovici
Journal:  J Mol Neurosci       Date:  2014-07-31       Impact factor: 3.444

8.  Modulation of placental alkaline phosphatase activity and cytokeratins in human HN-1 cells by butyrate, retinoic acid, catecholamines and histamine.

Authors:  J T Bijman; D J Wagener; H van Rennes; J M Wessels; F C Ramaekers; P van den Broek
Journal:  Br J Cancer       Date:  1987-08       Impact factor: 7.640

9.  Interactions between receptors for interleukin 2 and interleukin 4 on lines of helper T cells (HT-2) and B lymphoma cells (BCL1).

Authors:  R Fernandez-Botran; V M Sanders; E S Vitetta
Journal:  J Exp Med       Date:  1989-02-01       Impact factor: 14.307
  9 in total

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