Pim J van Leeuwen1, Maarten Donswijk2, Rohan Nandurkar3, Phillip Stricker4,5, Bao Ho6, Stijn Heijmink7, Esther M K Wit1, Corinne Tillier1, Erik van Muilenkom1, Quoc Nguyen4, Henk G van der Poel1, Louise Emmett3,4,6. 1. Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. 2. Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands. 3. Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia. 4. The Australian Prostate Cancer Research Centre-NSW, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia. 5. St Vincent's Clinic, Sydney, New South Wales, Australia. 6. Department of Theranostics and Nuclear Medicine, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia. 7. Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Abstract
OBJECTIVE: To determine the value of gallium-68-prostate-specific membrane antigen (68 Ga-PSMA)-11 positron emission tomography (PET) /computed tomography (CT) in men with newly diagnosed prostate cancer. PATIENTS AND METHODS: We analysed results of 140 men with intermediate- and high-risk prostate cancer. All men underwent 68 Ga-PSMA-11 PET/CT and multiparametric magnetic resonance imaging (mpMRI) before radical prostatectomy (RP) with extended pelvic lymph node (LN) dissection. For each patient, the clinical and pathological features were recorded. Prostate-specific antigen (PSA) was documented at staging scan, and after RP, at a median (interquartile range) of 110 (49-132) days. A PSA level of ≥0.03 ng/mL was classified as biochemical persistence (BCP). Logistic regression was performed for association of clinical variables and BCP. RESULTS: In these 140 patients with intermediate- and high-risk prostate cancer, 27.1% had PSMA PET/CT-positive findings in the pelvic LNs. Sensitivity and specificity for detection of LN metastases were 53% and 88% (PSMA PET/CT) and 14% and 99% (mpMRI), respectively. The overall BCP rate was 25.7%. The BCP rate was 16.7% in men who were PSMA PET/CT LN-negative compared to 50% in men who were PSMA PET/CT LN-positive (P < 0.05). The presence of PSMA-positive pelvic LNs was more predictive of BCP after RP than cT-stage, PSA level, and the Gleason score, adjusted for surgical margins status. CONCLUSIONS: 68 Ga-PSMA-11 PET/CT is highly predictive of BCP after RP, and should play an important role informing men with intermediate- or high-risk prostate cancer.
OBJECTIVE: To determine the value of gallium-68-prostate-specific membrane antigen (68 Ga-PSMA)-11 positron emission tomography (PET) /computed tomography (CT) in men with newly diagnosed prostate cancer. PATIENTS AND METHODS: We analysed results of 140 men with intermediate- and high-risk prostate cancer. All men underwent 68 Ga-PSMA-11 PET/CT and multiparametric magnetic resonance imaging (mpMRI) before radical prostatectomy (RP) with extended pelvic lymph node (LN) dissection. For each patient, the clinical and pathological features were recorded. Prostate-specific antigen (PSA) was documented at staging scan, and after RP, at a median (interquartile range) of 110 (49-132) days. A PSA level of ≥0.03 ng/mL was classified as biochemical persistence (BCP). Logistic regression was performed for association of clinical variables and BCP. RESULTS: In these 140 patients with intermediate- and high-risk prostate cancer, 27.1% had PSMA PET/CT-positive findings in the pelvic LNs. Sensitivity and specificity for detection of LN metastases were 53% and 88% (PSMA PET/CT) and 14% and 99% (mpMRI), respectively. The overall BCP rate was 25.7%. The BCP rate was 16.7% in men who were PSMA PET/CT LN-negative compared to 50% in men who were PSMA PET/CT LN-positive (P < 0.05). The presence of PSMA-positive pelvic LNs was more predictive of BCP after RP than cT-stage, PSA level, and the Gleason score, adjusted for surgical margins status. CONCLUSIONS: 68 Ga-PSMA-11 PET/CT is highly predictive of BCP after RP, and should play an important role informing men with intermediate- or high-risk prostate cancer.
Authors: Francesco Ceci; Daniela E Oprea-Lager; Louise Emmett; Judit A Adam; Jamshed Bomanji; Johannes Czernin; Matthias Eiber; Uwe Haberkorn; Michael S Hofman; Thomas A Hope; Rakesh Kumar; Steven P Rowe; Sarah M Schwarzenboeck; Stefano Fanti; Ken Herrmann Journal: Eur J Nucl Med Mol Imaging Date: 2021-02-19 Impact factor: 9.236
Authors: Dennie Meijer; Pim J van Leeuwen; Maarten L Donswijk; Thierry N Boellaard; Ivo G Schoots; Henk G van der Poel; Harry N Hendrikse; Daniela E Oprea-Lager; André N Vis Journal: BJU Int Date: 2021-06-16 Impact factor: 5.969
Authors: Henk B Luiting; Pim J van Leeuwen; Martijn B Busstra; Tessa Brabander; Henk G van der Poel; Maarten L Donswijk; André N Vis; Louise Emmett; Phillip D Stricker; Monique J Roobol Journal: BJU Int Date: 2019-11-29 Impact factor: 5.588
Authors: Sungmin Woo; Soleen Ghafoor; Anton S Becker; Sangwon Han; Andreas G Wibmer; Hedvig Hricak; Irene A Burger; Heiko Schöder; Hebert Alberto Vargas Journal: Eur J Hybrid Imaging Date: 2020-09-09
Authors: B H E Jansen; Y J L Bodar; G J C Zwezerijnen; D Meijer; J P van der Voorn; J A Nieuwenhuijzen; M Wondergem; T A Roeleveld; R Boellaard; O S Hoekstra; R J A van Moorselaar; D E Oprea-Lager; A N Vis Journal: Eur J Nucl Med Mol Imaging Date: 2020-08-12 Impact factor: 9.236