Literature DB >> 3007454

The murine transforming growth factor-beta precursor.

R Derynck, J A Jarrett, E Y Chen, D V Goeddel.   

Abstract

Transforming growth factor-beta (TGF-beta) is a homodimeric polypeptide which can act, often in cooperation with other growth factors, as a mitogenic factor for a variety of cells. TGF-beta can also exert growth inhibitory activity on many other cell lines. We have isolated cDNAs coding for the murine TGF-beta cDNA precursor. The deduced amino acid sequence localizes the 112-amino acid long TGF-beta monomer to the C terminus of the precursor. Two areas of the precursor exhibit a marked degree of homology to the human counterpart. One of these regions comprises the mature TGF-beta monomer, while the other corresponds to the NH2 terminus of the precursor and suggests an important biological function for this area. Northern hybridization results identify a major 2.5-kilobase TGF-beta mRNA and several minor TGF-beta mRNA species.

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Year:  1986        PMID： 3007454

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  93 in total

1.  Transforming growth factor-ßs as modulators of pericellular proteolytic events.

Authors:  J Keski-Oja; J Lohi; M Laiho
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

2.  Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.

Authors:  S J Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

3.  Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells.

Authors:  Yasushi Shintani; Margaret J Wheelock; Keith R Johnson
Journal:  Mol Biol Cell       Date:  2006-04-19       Impact factor: 4.138

4.  Inhibition of murine nephritogenic effector T cells by a clone-specific suppressor factor.

Authors:  C M Meyers; C J Kelly
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

5.  Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma.

Authors:  J LaMarre; B B Wolf; E L Kittler; P J Quesenberry; S L Gonias
Journal:  J Clin Invest       Date:  1993-03       Impact factor: 14.808

6.  Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

Authors:  Y Miyazaki; K Araki; C Vesin; I Garcia; Y Kapanci; J A Whitsett; P F Piguet; P Vassalli
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

7.  A GC-rich domain with bifunctional effects on mRNA and protein levels: implications for control of transforming growth factor beta 1 expression.

Authors:  L Scotto; R K Assoian
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

8.  Development of a retroviral vector for inducible expression of transforming growth factor beta 1.

Authors:  M L McGeady; P M Arthur; M Seidman
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

9.  Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

Authors:  D F Pierce; A E Gorska; A Chytil; K S Meise; D L Page; R J Coffey; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

10.  Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

Authors:  T Yamamoto; T Nakamura; N A Noble; E Ruoslahti; W A Border
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205
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