| Literature DB >> 30074401 |
Dongfeng Wang1,2, Jian Li1,2, Fengling Cai1,2, Zhi Xu1,2, Li Li1,2, Huanfeng Zhu1,2, Wei Liu1,2, Qingyu Xu1,2, Jian Cao1,2, Jingfeng Sun1,2, Jinhai Tang3.
Abstract
Breast cancer is the most frequent malignant disease in women worldwide. It is a heterogeneous and complex genetic disease with different molecular characteristics. MAPT-AS1, a long non-coding RNA (lncRNA) existing at the anti-sense strand of the MAPT (microtubule associated protein tau) promoter region, was believed to regulate MAPT, which was associated with disease state in Parkinson's disease. But the role of MAPT-AS1 in breast cancer has never been reported. In our study we found that MAPT-AS1 is overexpressed in breast cancer but not in triple negative breast cancer (TNBC), and that high expression of MAPT-AS1 was correlated with better patient survival. In addition, the level of MAPT-AS1 was correlated with the expression of MAPT, and MAPT was associated with survival time in breast cancer. Our study suggests that MAPT-AS1 may play a role and be a potential survival predictive biomarker in breast cancer.Entities:
Keywords: MAPT-AS1; breast cancer; cancer du sein; long ARN non codant; long non-coding RNA; patient survival; survie des patientes
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Year: 2018 PMID： 30074401 DOI： 10.1139/bcb-2018-0039
Source DB: PubMed Journal: Biochem Cell Biol ISSN： 0829-8211 Impact factor: 3.626