Literature DB >> 30074146

Kinsenoside: A Promising Bioactive Compound from Anoectochilus Species.

Chang-Xing Qi1, Qun Zhou1, Zhou Yuan1, Zeng-Wei Luo1, Chong Dai1, Hu-Cheng Zhu1, Chun-Mei Chen1, Yong-Bo Xue1, Jian-Ping Wang1, Ya-Fen Wang1, Ya-Ping Liu1, Ming Xiang1, Wei-Guang Sun1, Jin-Wen Zhang2, Yong-Hui Zhang3.   

Abstract

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects, including hepatoprotective, anti-hyperglycemic, anti-hyperliposis, anti-inflammatory, vascular protective and anti-osteoporosis effects and so on, which is contributing to its promising potency in disease treatments. This review aims to recapitulate the pharmacological functions of kinsenoside, as well as its source, extraction, identification, quantitative analysis, pharmacokinetics, synthesis and patent information. The data reported in this work can confirm the therapeutic potential of kinsenoside and provide useful information for further new drug development.

Entities:  

Keywords:  Anoectochilus roxburghii; bioactivity; kinsenoside; review; synthesis

Mesh：

Substances：

Year:  2018        PMID： 30074146     DOI： 10.1007/s11596-018-1841-1

Source DB:  PubMed          Journal:  Curr Med Sci        ISSN： 2523-899X


  20 in total

1.  Antitumor and immunostimulating effects of Anoectochilus formosanus Hayata.

Authors:  C-C Tseng; H-F Shang; L-F Wang; B Su; C-C Hsu; H-Y Kao; K-T Cheng
Journal:  Phytomedicine       Date:  2005-09-16       Impact factor: 5.340

2.  Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats.

Authors:  C C Shih; Y W Wu; W C Lin
Journal:  Phytomedicine       Date:  2005-06       Impact factor: 5.340

3.  Higher yielding isolation of kinsenoside in Anoectochilus and its antihyperliposis effect.

Authors:  X Du; N Sun; T Tamura; A Mohri; M Sugiura; T Yoshizawa; N Irino; J Hayashi; Y Shoyama
Journal:  Biol Pharm Bull       Date:  2001-01       Impact factor: 2.233

4.  A novel total synthesis of kinsenoside and goodyeroside A relying on the efficient reaction of the chiral 2(5H)-furanones.

Authors:  Xiang Zhang; Hai-Hong Huang; Qing-Hun Chen
Journal:  J Asian Nat Prod Res       Date:  2005-10       Impact factor: 1.569

5.  Kinsenoside-mediated lipolysis through an AMPK-dependent pathway in C3H10T1/2 adipocytes: Roles of AMPK and PPARα in the lipolytic effect of kinsenoside.

Authors:  Kur-Ta Cheng; Yu-Shiou Wang; Hsiu-Chu Chou; Chih-Cheng Chang; Ching-Kuo Lee; Shu-Hui Juan
Journal:  Phytomedicine       Date:  2015-04-28       Impact factor: 5.340

6.  Kinsenoside, a high yielding constituent from Anoectochilus formosanus, inhibits carbon tetrachloride induced Kupffer cells mediated liver damage.

Authors:  Wen-Tsong Hsieh; Chia-Tzu Tsai; Jin-Bin Wu; Hung-Bo Hsiao; Li-Chan Yang; Wen-Chuan Lin
Journal:  J Ethnopharmacol       Date:  2011-04-04       Impact factor: 4.360

7.  Kinsenoside isolated from Anoectochilus formosanus suppresses LPS-stimulated inflammatory reactions in macrophages and endotoxin shock in mice.

Authors:  Hung-Bo Hsiao; Jin-Bin Wu; Ho Lin; Wen-Chuan Lin
Journal:  Shock       Date:  2011-02       Impact factor: 3.454

Review 8.  Pharmacologically active compounds in the Anoectochilus and Goodyera species.

Authors:  Xiao-Ming Du; Nobuto Irino; Norihiro Furusho; Jun Hayashi; Yukihiro Shoyama
Journal:  J Nat Med       Date:  2008-01-18       Impact factor: 2.343

9.  Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses.

Authors:  Hung-Bo Hsiao; Chang-Chi Hsieh; Jin-Bin Wu; Ho Lin; Wen-Chuan Lin
Journal:  BMC Complement Altern Med       Date:  2016-02-25       Impact factor: 3.659

10.  In Vitro Assessment of CYP-Mediated Drug Interactions for Kinsenoside, an Antihyperlipidemic Candidate.

Authors:  Shaheed Ur Rehman; Min Sun Choi; In Sook Kim; Zengwei Luo; Yongbo Xue; Guangming Yao; Yonghui Zhang; Hye Hyun Yoo
Journal:  Molecules       Date:  2016-06-18       Impact factor: 4.411
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  10 in total

1.  Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy.

Authors:  Peter Smoak; Susan J Burke; J Jason Collier
Journal:  SN Compr Clin Med       Date:  2021-08-15

2.  Kinsenoside Protects Against Radiation-Induced Liver Fibrosis via Downregulating Connective Tissue Growth Factor Through TGF-β1 Signaling.

Authors:  Xiaoqi Nie; Qianqian Yu; Long Li; Minxiao Yi; Bili Wu; Yongbiao Huang; Yonghui Zhang; Hu Han; Xianglin Yuan
Journal:  Front Pharmacol       Date:  2022-01-21       Impact factor: 5.810

3.  The Activation of AMPK/NRF2 Pathway in Lung Epithelial Cells Is Involved in the Protective Effects of Kinsenoside on Lipopolysaccharide-Induced Acute Lung Injury.

Authors:  Yue Yang; Zhen-Tong Zhong; Yong-Guang Xiao; Hong-Bin Chen
Journal:  Oxid Med Cell Longev       Date:  2022-03-18       Impact factor: 6.543

Review 4.  Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders.

Authors:  Li Lu; Yuan Xiong; Ze Lin; Xiangyu Chu; Adriana C Panayi; Yiqiang Hu; Juan Zhou; Bobin Mi; Guohui Liu
Journal:  Front Pharmacol       Date:  2022-10-04       Impact factor: 5.988

5.  Induction, Proliferation, Regeneration and Kinsenoside and Flavonoid Content Analysis of the Anoectochilus roxburghii (Wall.) Lindl Protocorm-like Body.

Authors:  Hongzhen Wang; Xinying Chen; Xiaoyun Yan; Zhixia Xu; Qingsong Shao; Xueqian Wu; Lingjuan Tou; Li Fang; Mingming Wei; Huasen Wang
Journal:  Plants (Basel)       Date:  2022-09-21

6.  Hepatoprotective Effects of Polysaccharide from Anoectochilus roxburghii (Wall.) Lindl. on Rat Liver Injury Induced by CCl4.

Authors:  Xiaoling Yu; Lingyi Huang; Chen You; Liying Huang
Journal:  Drug Des Devel Ther       Date:  2021-07-06       Impact factor: 4.162

7.  Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis.

Authors:  Jiaxiong Ming; Qianqian Xu; Limin Gao; Yanfang Deng; Jie Yin; Qun Zhou; Qingyi Tong; Yonghui Zhang
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-11

8.  Optimization of Ultrasound Assisted Extraction (UAE) of Kinsenoside Compound from Anoectochilus roxburghii (Wall.) Lindl by Response Surface Methodology (RSM).

Authors:  Biyun Yang; Mengyuan Zhang; Haiyong Weng; Yong Xu; Lihui Zeng
Journal:  Molecules       Date:  2020-01-02       Impact factor: 4.411

9.  Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway.

Authors:  Ming Xiang; Tingting Liu; Cheng Tian; Kun Ma; Jing Gou; Rongrong Huang; Senlin Li; Qing Li; Chuanrui Xu; Lei Li; Chih-Hao Lee; Yonghui Zhang
Journal:  Pharmacol Res       Date:  2022-01-21       Impact factor: 7.658

10.  Kinsenoside Alleviates Alcoholic Liver Injury by Reducing Oxidative Stress, Inhibiting Endoplasmic Reticulum Stress, and Regulating AMPK-Dependent Autophagy.

Authors:  Limin Gao; Xingyu Chen; Zeyu Fu; Jie Yin; Yafen Wang; Weiguang Sun; Hong Ren; Yonghui Zhang
Journal:  Front Pharmacol       Date:  2022-01-18       Impact factor: 5.810
  10 in total

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