Literature DB >> 30073838

Discovery of (Dihydro)pyrazine N-Oxides via Genome Mining in Pseudomonas.

Ashley M Kretsch1, Gina L Morgan1, Jillian Tyrrell1, Emily Mevers2, Isabelle Vallet-Gély3, Bo Li1.   

Abstract

Overexpression of the Pseudomonas virulence factor ( pvf) biosynthetic operon led to the identification of a family of pyrazine N-oxides (PNOs), including a novel dihydropyrazine N,N'-dioxide (dPNO) metabolite. The nonribosomal peptide synthetase responsible for production of (d)PNOs was characterized, and a biosynthetic pathway for (d)PNOs was proposed. This work highlights the unique chemistry catalyzed by pvf-encoded enzymes and sets the stage for bioactivity studies of the metabolites produced by the virulence pathway.

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Year:  2018        PMID： 30073838      PMCID： PMC6195765          DOI： 10.1021/acs.orglett.8b01944

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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