Literature DB >> 30072392

Intracranial Response to Anti-Programmed Death 1 Therapy in a Patient with Metastatic Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis.

Suneel D Kamath1, Priya U Kumthekar2, Tim J Kruser3, Nisha A Mohindra4,5.   

Abstract

Central nervous system metastasis in non-small cell lung cancer remains a therapeutic challenge and confers a poor prognosis. Here we describe a patient with lung adenocarcinoma, parenchymal brain metastases, and leptomeningeal carcinomatosis who demonstrated a sustained response to programmed death 1 inhibition combined with stereotactic radiosurgery. © AlphaMed Press 2018.

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Year:  2018        PMID： 30072392      PMCID： PMC6292532          DOI： 10.1634/theoncologist.2018-0022

Source DB:  PubMed          Journal:  Oncologist        ISSN： 1083-7159


  9 in total

1.  Intracranial response to nivolumab in NSCLC patients with untreated or progressing CNS metastases.

Authors:  Elizabeth Dudnik; Shlomit Yust-Katz; Hovav Nechushtan; Daniel A Goldstein; Alona Zer; Dov Flex; Tali Siegal; Nir Peled
Journal:  Lung Cancer       Date:  2016-05-31       Impact factor: 5.705

2.  Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer.

Authors:  L Tiffany Lyle; Paul R Lockman; Chris E Adkins; Afroz Shareef Mohammad; Emily Sechrest; Emily Hua; Diane Palmieri; David J Liewehr; Seth M Steinberg; Wojciech Kloc; Ewa Izycka-Swieszewska; Renata Duchnowska; Naema Nayyar; Priscilla K Brastianos; Patricia S Steeg; Brunilde Gril
Journal:  Clin Cancer Res       Date:  2016-05-31       Impact factor: 12.531

3.  Symptomatic leptomeningeal metastasis improvement with nivolumab in advanced non-small cell lung cancer patient.

Authors:  Maria Gion; Jordi Remon; Caroline Caramella; Jean-Charles Soria; Benjamin Besse
Journal:  Lung Cancer       Date:  2017-02-27       Impact factor: 5.705

4.  Development of leptomeningeal carcinomatosis during a marked response of brain metastases to pembrolizumab in a patient with non-small-cell lung cancer.

Authors:  K Otsubo; N Seki; Y Nakanishi; I Okamoto
Journal:  Ann Oncol       Date:  2018-03-01       Impact factor: 32.976

5.  Clinical outcome in patients with leptomeningeal metastasis from non-small cell lung cancer: Okayama Lung Cancer Study Group.

Authors:  Shigeki Umemura; Kazuya Tsubouchi; Hiroshige Yoshioka; Katsuyuki Hotta; Nagio Takigawa; Keiichi Fujiwara; Naokatsu Horita; Yoshihiko Segawa; Noboru Hamada; Ichiro Takata; Hiromichi Yamane; Haruhito Kamei; Katsuyuki Kiura; Mitsune Tanimoto
Journal:  Lung Cancer       Date:  2012-04-07       Impact factor: 5.705

Review 6.  Leptomeningeal carcinomatosis in non-small cell lung cancer patients: A continuing challenge in the personalized treatment era.

Authors:  J Remon; E Le Rhun; B Besse
Journal:  Cancer Treat Rev       Date:  2016-12-30       Impact factor: 12.111

7.  Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial.

Authors:  Paul D Brown; Kurt Jaeckle; Karla V Ballman; Elana Farace; Jane H Cerhan; S Keith Anderson; Xiomara W Carrero; Fred G Barker; Richard Deming; Stuart H Burri; Cynthia Ménard; Caroline Chung; Volker W Stieber; Bruce E Pollock; Evanthia Galanis; Jan C Buckner; Anthony L Asher
Journal:  JAMA       Date:  2016-07-26       Impact factor: 56.272

8.  Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial.

Authors:  Sarah B Goldberg; Scott N Gettinger; Amit Mahajan; Anne C Chiang; Roy S Herbst; Mario Sznol; Apostolos John Tsiouris; Justine Cohen; Alexander Vortmeyer; Lucia Jilaveanu; James Yu; Upendra Hegde; Stephanie Speaker; Matthew Madura; Amanda Ralabate; Angel Rivera; Elin Rowen; Heather Gerrish; Xiaopan Yao; Veronica Chiang; Harriet M Kluger
Journal:  Lancet Oncol       Date:  2016-06-03       Impact factor: 41.316

9.  Structural and functional features of central nervous system lymphatic vessels.

Authors:  Antoine Louveau; Igor Smirnov; Timothy J Keyes; Jacob D Eccles; Sherin J Rouhani; J David Peske; Noel C Derecki; David Castle; James W Mandell; Kevin S Lee; Tajie H Harris; Jonathan Kipnis
Journal:  Nature       Date:  2015-06-01       Impact factor: 49.962
  9 in total
  2 in total

1.  Expression of the Topoisomerase II Alpha (TOP2A) Gene in Lung Adenocarcinoma Cells and the Association with Patient Outcomes.

Authors:  Xiaomei Du; Zhiwen Xue; Jianning Lv; Heidou Wang
Journal:  Med Sci Monit       Date:  2020-12-27

2.  Whole brain radiotherapy (WBRT) for leptomeningeal metastasis from NSCLC in the era of targeted therapy: a retrospective study.

Authors:  Junjie Zhen; Lei Wen; Mingyao Lai; Zhaoming Zhou; Changguo Shan; Shaoqun Li; Tao Lin; Jie Wu; Wensheng Wang; Shaoqiang Xu; Da Liu; Ming Lu; Dan Zhu; Longhua Chen; Linbo Cai; Cheng Zhou
Journal:  Radiat Oncol       Date:  2020-07-31       Impact factor: 3.481
  2 in total

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