Michelle Hall1, Birgit Castelein2, Ruth Wittoek3, Patrick Calders2, Ans Van Ginckel4. 1. Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, University of Melbourne, Victoria, Australia. 2. Department of Rehabilitation Sciences, Ghent University Hospital Campus, Corneel Heymanslaan 10, Building 3B3, 9000 Ghent, Belgium. 3. Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. 4. Department of Rehabilitation Sciences, Ghent University Hospital Campus, Corneel Heymanslaan 10, Building 3B3, 9000 Ghent, Belgium. Electronic address: Ans.VanGinckel@UGent.be.
Abstract
OBJECTIVES: The purposes were to (i) determine the effect of diet-only treatments and combined diet and exercise treatments on pain and physical function and (ii) explore the effect of these treatments on inflammatory biomarkers in overweight and obese adults with knee osteoarthritis. METHODS: Five electronic databases were searched until March 2017. Randomised controlled trials investigating the effect of non-surgical non-pharmacological weight loss treatment, with or without exercise, on self-reported pain and/or physical function and/or inflammatory biomarkers were selected. Two review authors independently extracted data and assessed risk of bias for each study. Standardised mean differences (SMD) of outcomes were pooled as appropriate, using a random effects approach. RESULTS: 2676 articles were identified, 19 met review criteria and 9 met criteria for meta-analyses. Diet-only treatments did not reduce pain (SMD -0.13; 95% confidence interval, CI: -0.37, 0.10; I2 = 49%) while a combination of diet and exercise treatments did reduce pain moderately (SMD -0.37; 95%CI: -0.69, -0.04; I2 = 54%). Physical function improved moderately with diet treatments (SMD -0.30; 95%CI: -0.52, -0.08; I2 = 47%) and combined diet and exercise treatments (SMD -0.32; 95%CI: -0.56, -0.08; I2 = 24%). Of the inflammatory markers assessed, only IL-6 reduced with diet-only treatments (SMD -0.23; 95%CI: -0.45, -0.02; I2 = 0%). CONCLUSION: Overall, moderate pain-relief is achievable with a combination of diet and exercise, but potentially not with diet-only treatments. Findings support that either diet-only treatments or combined diet and exercise treatments moderately improve physical function. Overall, treatment effects on inflammatory biomarkers are questionable.
OBJECTIVES: The purposes were to (i) determine the effect of diet-only treatments and combined diet and exercise treatments on pain and physical function and (ii) explore the effect of these treatments on inflammatory biomarkers in overweight and obese adults with knee osteoarthritis. METHODS: Five electronic databases were searched until March 2017. Randomised controlled trials investigating the effect of non-surgical non-pharmacological weight loss treatment, with or without exercise, on self-reported pain and/or physical function and/or inflammatory biomarkers were selected. Two review authors independently extracted data and assessed risk of bias for each study. Standardised mean differences (SMD) of outcomes were pooled as appropriate, using a random effects approach. RESULTS: 2676 articles were identified, 19 met review criteria and 9 met criteria for meta-analyses. Diet-only treatments did not reduce pain (SMD -0.13; 95% confidence interval, CI: -0.37, 0.10; I2 = 49%) while a combination of diet and exercise treatments did reduce pain moderately (SMD -0.37; 95%CI: -0.69, -0.04; I2 = 54%). Physical function improved moderately with diet treatments (SMD -0.30; 95%CI: -0.52, -0.08; I2 = 47%) and combined diet and exercise treatments (SMD -0.32; 95%CI: -0.56, -0.08; I2 = 24%). Of the inflammatory markers assessed, only IL-6 reduced with diet-only treatments (SMD -0.23; 95%CI: -0.45, -0.02; I2 = 0%). CONCLUSION: Overall, moderate pain-relief is achievable with a combination of diet and exercise, but potentially not with diet-only treatments. Findings support that either diet-only treatments or combined diet and exercise treatments moderately improve physical function. Overall, treatment effects on inflammatory biomarkers are questionable.
Authors: Danielle N D'Erminio; Divya Krishnamoorthy; Alon Lai; Robert C Hoy; Devorah M Natelson; Jashvant Poeran; Andrew Torres; Damien M Laudier; Philip Nasser; Deepak Vashishth; Svenja Illien-Jünger; James C Iatridis Journal: J Orthop Res Date: 2021-10-21 Impact factor: 3.102
Authors: Michelle Hall; Rana S Hinman; Gabrielle Knox; Libby Spiers; Priya Sumithran; Nicholas J Murphy; Fiona McManus; Karen E Lamb; Flavia Cicuittini; David J Hunter; Stephen P Messier; Kim L Bennell Journal: BMC Musculoskelet Disord Date: 2022-03-05 Impact factor: 2.362
Authors: Shazia Jehan; Ferdinand Zizi; Seithikurippu R Pandi-Perumal; Samy I McFarlane; Girardin Jean-Louis; Alyson K Myers Journal: Adv Obes Weight Manag Control Date: 2020-10-29