Literature DB >> 3007202

VIP and histamine H2 receptor activity in human fetal gastric glands.

S Emami, E Chastre, N Mulliez, M Gonzales, C Gespach.   

Abstract

Vasoactive intestinal peptide (VIP, EC50 = 6.4 X 10(-10)M) and histamine (EC50 = 3 X 10(-6)M) activated the cyclic AMP generating system in gastric glands isolated from two human fetuses at 23 weeks gestation. Histamine antagonism by the H2 receptor blockers cimetidine (Ki = 0.35 X 10(-6)M) and ranitidine (ki = 0.51 X 10(-7)M) clearly characterized the histaminic activation as being of the H2 type. It is suggested that these two vasoactive hormones may operate as neurocrine/paracrine regulators of the differentiation and/or function of the human gastric mucosa in utero.

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Year:  1986        PMID： 3007202     DOI： 10.1007/bf02118640

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  30 in total

1.  Vasoactive intestinal peptide receptor activity and specificity during enterocyte-like differentiation and retrodifferentiation of the human colonic cancerous subclone HT29-18.

Authors:  E Chastre; S Emami; G Rosselin; C Gespach
Journal:  FEBS Lett       Date:  1985-09-02       Impact factor: 4.124

2.  Histidine decarboxylase and DOPA decarboxylase in the stomach of the developing rat.

Authors:  D Aures; R Håkanson
Journal:  Experientia       Date:  1968-07-15

3.  [Functional and specific vasoactive intestinal peptide receptors in enterocytes isolated from fetal or adult rats].

Authors:  E Chastre; C Gespach; G Rosselin; Y Broer
Journal:  C R Acad Sci III       Date:  1985

4.  Vasoactive intestinal peptide receptor activity in human fetal enterocytes.

Authors:  C Gespach; E Chastre; S Emami; N Mulliez
Journal:  FEBS Lett       Date:  1985-01-28       Impact factor: 4.124

5.  Histamine H2 receptor activity during the differentiation of the human monocytic-like cell line U-937. Comparison with prostaglandins and isoproterenol.

Authors:  C Gespach; H Cost; J P Abita
Journal:  FEBS Lett       Date:  1985-05-20       Impact factor: 4.124

6.  Development of intestinal regulatory peptides in the human fetus.

Authors:  M G Bryant; A M Buchan; M Gregor; M A Ghatei; J M Polak; S R Bloom
Journal:  Gastroenterology       Date:  1982-07       Impact factor: 22.682

7.  Ontogeny of gastric acidity in the ovine fetus.

Authors:  A Shulkes; P Chick; K J Hardy; P Robinson; J Trahair
Journal:  J Dev Physiol       Date:  1985-06

8.  Development of sensitivity to cAMP-inducing hormones in the rat stomach.

Authors:  C Gespach; Y Cherel; G Rosselin
Journal:  Am J Physiol       Date:  1984-09

9.  Desensitization by histamine of H2 receptor-mediated adenylate cyclase activation in the human gastric cancer cell line HGT-1.

Authors:  A Prost; S Emami; C Gespach
Journal:  FEBS Lett       Date:  1984-11-19       Impact factor: 4.124

10.  Action of histamine and vasoactive intestinal peptide (VIP) on cyclic AMP in gastric glands isolated from human fetal stomach.

Authors:  C Gespach; C Dupont; G Rosselin
Journal:  Experientia       Date:  1981
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