Literature DB >> 3007061

Isolation and characterization of the alpha 1-antitrypsin gene of mice.

K S Krauter, B A Citron, M T Hsu, D Powell, J E Darnell.   

Abstract

We have characterized a genomic clone of the mouse equivalent of alpha1-antitrypsin (alpha1-antiprotease) a gene that is expressed in liver. There are at least three other genomic sequences similar to the gene expressed in mouse liver and all appear to be located on chromosome 12. The duplicated regions might include genes that are also expressed in the liver and/or in other tissues. Comparison of the sequences of the mouse alpha1-antitrypsin sequence expressed in liver with sequences of alpha1-antitrypsins from other mammals reveals great homology in the coding regions, particularly in the amino acids at the active site, including the neighboring methionine and serine thought to play a key role in the protease inhibition.

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Year:  1986        PMID： 3007061     DOI： 10.1089/dna.1986.5.29

Source DB:  PubMed          Journal:  DNA        ISSN： 0198-0238


  16 in total

Review 1.  Mouse chromosome 12.

Authors:  P D'Eustachio
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Protease nexin I (PNI) in mouse brain is expressed from the same gene as in seminal vesicle.

Authors:  B A Citron; K T Ratzlaff; I V Smirnova; B W Festoff
Journal:  J Mol Neurosci       Date:  1996       Impact factor: 3.444

3.  Tissue-specific gene expression in mouse hepatocytes cultured in growth-restricting medium.

Authors:  T Spiegelberg; J O Bishop
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

4.  A cell-specific enhancer of the mouse alpha 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites.

Authors:  D R Grayson; R H Costa; K G Xanthopoulos; J E Darnell
Journal:  Mol Cell Biol       Date:  1988-03       Impact factor: 4.272

5.  Highly conserved upstream regions of the alpha 1-antitrypsin gene in two mouse species govern liver-specific expression by different mechanisms.

Authors:  J J Latimer; F G Berger; H Baumann
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

6.  Evolution of murine alpha 1-proteinase inhibitors: gene amplification and reactive center divergence.

Authors:  C Rheaume; R L Goodwin; J J Latimer; H Baumann; F G Berger
Journal:  J Mol Evol       Date:  1994-02       Impact factor: 2.395

7.  Aryl hydrocarbon induction of rat cytochrome P-450d results from increased precursor RNA processing.

Authors:  G Silver; K S Krauter
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

8.  Reactive site polymorphism in the murine protease inhibitor gene family is delineated using a modification of the PCR reaction (PCR + 1).

Authors:  F Borriello; K S Krauter
Journal:  Nucleic Acids Res       Date:  1990-09-25       Impact factor: 16.971

9.  Tissue- and species-specific regulation of murine alpha 1-antitrypsin gene transcription.

Authors:  C Rheaume; J J Latimer; H Baumann; F G Berger
Journal:  J Biol Chem       Date:  1988-10-15       Impact factor: 5.157

10.  The equine major plasma serpin multigene family: partial characterization including sequence of the reactive-site regions.

Authors:  S D Patterson; K Bell; D C Shaw
Journal:  Biochem Genet       Date:  1991-10       Impact factor: 1.890
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