Literature DB >> 30070266

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy.

Oliver Jonas1, Jeon Woong Kang, Surya P Singh, Alex Lammers, Freddy T Nguyen, Ramachandra R Dasari, Peter T C So, Robert Langer, Michael J Cima.   

Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

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Year:  2018        PMID： 30070266      PMCID： PMC6175619          DOI： 10.1039/c8an00913a

Source DB:  PubMed          Journal:  Analyst        ISSN： 0003-2654            Impact factor:   4.616


  28 in total

Review 1.  Prospects for in vivo Raman spectroscopy.

Authors:  E B Hanlon; R Manoharan; T W Koo; K E Shafer; J T Motz; M Fitzmaurice; J R Kramer; I Itzkan; R R Dasari; M S Feld
Journal:  Phys Med Biol       Date:  2000-02       Impact factor: 3.609

Review 2.  Single cell Raman spectroscopy for cell sorting and imaging.

Authors:  Mengqiu Li; Jian Xu; Maria Romero-Gonzalez; Steve A Banwart; Wei E Huang
Journal:  Curr Opin Biotechnol       Date:  2011-12-02       Impact factor: 9.740

Review 3.  Controlling gene expression in response to stress.

Authors:  Eulàlia de Nadal; Gustav Ammerer; Francesc Posas
Journal:  Nat Rev Genet       Date:  2011-11-03       Impact factor: 53.242

Review 4.  Application of micro- and nano-electromechanical devices to drug delivery.

Authors:  Mark Staples; Karen Daniel; Michael J Cima; Robert Langer
Journal:  Pharm Res       Date:  2006-05-05       Impact factor: 4.200

5.  High resolution live cell Raman imaging using subcellular organelle-targeting SERS-sensitive gold nanoparticles with highly narrow intra-nanogap.

Authors:  Jeon Woong Kang; Peter T C So; Ramachandra R Dasari; Dong-Kwon Lim
Journal:  Nano Lett       Date:  2015-02-11       Impact factor: 11.189

Review 6.  Tumors as organs: complex tissues that interface with the entire organism.

Authors:  Mikala Egeblad; Elizabeth S Nakasone; Zena Werb
Journal:  Dev Cell       Date:  2010-06-15       Impact factor: 12.270

7.  Noninvasive Monitoring of Blood Glucose with Raman Spectroscopy.

Authors:  Rishikesh Pandey; Santosh Kumar Paidi; Tulio A Valdez; Chi Zhang; Nicolas Spegazzini; Ramachandra Rao Dasari; Ishan Barman
Journal:  Acc Chem Res       Date:  2017-01-10       Impact factor: 22.384

8.  Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

Authors:  Timothy R Wilson; Jane Fridlyand; Yibing Yan; Elicia Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Yulei Wang; Jeff Sosman; Antoni Ribas; Jiang Li; John Moffat; Daniel P Sutherlin; Hartmut Koeppen; Mark Merchant; Richard Neve; Jeff Settleman
Journal:  Nature       Date:  2012-07-26       Impact factor: 49.962

9.  Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.

Authors:  Elizabeth S Nakasone; Hanne A Askautrud; Tim Kees; Jae-Hyun Park; Vicki Plaks; Andrew J Ewald; Miriam Fein; Morten G Rasch; Ying-Xim Tan; Jing Qiu; Juwon Park; Pranay Sinha; Mina J Bissell; Eirik Frengen; Zena Werb; Mikala Egeblad
Journal:  Cancer Cell       Date:  2012-04-17       Impact factor: 31.743

Review 10.  Clinical instrumentation and applications of Raman spectroscopy.

Authors:  Isaac Pence; Anita Mahadevan-Jansen
Journal:  Chem Soc Rev       Date:  2016-04-07       Impact factor: 54.564
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  3 in total

1.  A Miniaturized Platform for Multiplexed Drug Response Imaging in Live Tumors.

Authors:  Sharath Bhagavatula; Devon Thompson; Sebastian W Ahn; Kunj Upadhyaya; Alex Lammers; Kyle Deans; Christine Dominas; Benjamin Ferland; Veronica Valvo; Guigen Liu; Oliver Jonas
Journal:  Cancers (Basel)       Date:  2021-02-06       Impact factor: 6.639

2.  Intratarget Microdosing for Deep Phenotyping of Multiple Drug Effects in the Live Brain.

Authors:  Jennifer Kim; Sebastian W Ahn; Kyle Deans; Devon Thompson; Benjamin Ferland; Prajan Divakar; Christine Dominas; Oliver Jonas
Journal:  Front Bioeng Biotechnol       Date:  2022-03-18

3.  Machine-learning aided in situ drug sensitivity screening predicts treatment outcomes in ovarian PDX tumors.

Authors:  Max J Cotler; Khalil B Ramadi; Xiaonan Hou; Elena Christodoulopoulos; Sebastian Ahn; Ashvin Bashyam; Huiming Ding; Melissa Larson; Ann L Oberg; Charles Whittaker; Oliver Jonas; Scott H Kaufmann; S John Weroha; Michael J Cima
Journal:  Transl Oncol       Date:  2022-04-26       Impact factor: 4.803
  3 in total

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