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Literature DB >> 3006888

Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro.

Abstract

Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated 45Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3006888 DOI： 10.1007/bf02556841

Source DB: PubMed Journal: Calcif Tissue Int ISSN： 0171-967X Impact factor: 4.333

15 in total

1. Prostaglandins: stimulation of bone resorption in tissue culture.

Authors: D C Klein; L G Raisz
Journal: Endocrinology Date: 1970-06 Impact factor: 4.736

2. Omeprazole, a specific inhibitor of gastric (H+-K+)-ATPase, is a H+-activated oxidizing agent of sulfhydryl groups.

Authors: W B Im; J C Sih; D P Blakeman; J P McGrath
Journal: J Biol Chem Date: 1985-04-25 Impact factor: 5.157

3. Possible antagonists to gastrin in parathyroid adenomas.

Authors: C Mollerup; H E Cartensen; E Bruun; L A Christiansen; G Stage
Journal: Br J Surg Date: 1980-12 Impact factor: 6.939

4. High active isoenzyme of carbonic anhydrase in rat calvaria osteoclasts. Immunohistochemical study.

Authors: H K Väänänen; E K Parvinen
Journal: Histochemistry Date: 1983

5. Inhibition of gastric acid secretion by omeprazole in the dog and rat.

Authors: H Larsson; E Carlsson; U Junggren; L Olbe; S E Sjöstrand; I Skånberg; G Sundell
Journal: Gastroenterology Date: 1983-10 Impact factor: 22.682

6. Immunohistochemical localization of carbonic anhydrase isoenzymes I and II in human bone, cartilage and giant cell tumor.

Authors: H K Väänänen
Journal: Histochemistry Date: 1984

7. Role of endogenous calcitonin in the secretion of gastrin and gastric acid in rats.

Authors: H Ito; T Sakurada; H Orimo
Journal: Horm Metab Res Date: 1977-01 Impact factor: 2.936

8. Response of basal and pentagastrin-stimulated gastric secretion and of serum gastrin to short- and long-term intravenous infusion of salmon calcitonin in hyperchlorhydric subjects.

Authors: F Paul; F Neumann; H Huchzermeyer
Journal: Scand J Gastroenterol Date: 1978 Impact factor: 2.423

9. Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification.

Authors: W S Sly; D Hewett-Emmett; M P Whyte; Y S Yu; R E Tashian
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

10. Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture.

Authors: C Minkin; J M Jennings
Journal: Science Date: 1972-06-02 Impact factor: 47.728

52 in total

1. Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative.

Authors: Shelly L Gray; Andrea Z LaCroix; Joseph Larson; John Robbins; Jane A Cauley; JoAnn E Manson; Zhao Chen
Journal: Arch Intern Med Date: 2010-05-10

2. Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy.

Authors: M Krause; J Keller; B Beil; I van Driel; J Zustin; F Barvencik; T Schinke; M Amling
Journal: Osteoporos Int Date: 2014-11-13 Impact factor: 4.507

Review 3. Safety of proton pump inhibitors: current evidence for osteoporosis and interaction with antiplatelet agents.

Authors: David A Johnson
Journal: Curr Gastroenterol Rep Date: 2010-06

4. Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: a randomized, crossover, controlled clinical trial.

Authors: Matthew J Wright; Rebecca R Sullivan; Erin Gaffney-Stomberg; Donna M Caseria; Kimberly O O'Brien; Deborah D Proctor; Christine A Simpson; Jane E Kerstetter; Karl L Insogna
Journal: J Bone Miner Res Date: 2010-10 Impact factor: 6.741

5. The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: a population-based study [corrected] from the Canadian Multicentre Osteoporosis Study (CaMos).

Authors: Laura E Targownik; William D Leslie; K Shawn Davison; David Goltzman; Sophie A Jamal; Nancy Kreiger; Robert G Josse; Stephanie M Kaiser; Christopher S Kovacs; Jerilynn C Prior; Wei Zhou
Journal: Am J Gastroenterol Date: 2012-07-10 Impact factor: 10.864