| Literature DB >> 30064949 |
Yasuhiro Ikawa1, Toshihiro Fujiki2, Ryosei Nishimura3, Kazuhiro Noguchi2, Eri Koshino2, Akiko Fujiki4, Masaki Fukuda2, Rie Kuroda2, Shintaro Mase2, Raita Araki2, Hideaki Maeba2, Kimiyasu Shiraki5, Akihiro Yachie2.
Abstract
Resistant herpes simplex virus type 1 (HSV-1) infection is sometimes fatal for immunocompromised patients. Here, we report 10-year-old girl receiving hematopoietic stem cell transplantation developed refractory HSV-1 infection, which was persisted to intermittent acyclovir (ACV) or foscarnet (FOS) administrations but was improved by continuous ACV administration. The isolates from the lesion were identified with low susceptibilities to ACV and FOS by plaque reduction assay due to DNA pol gene mutation. Continuous ACV administration overcomes the efficacy of intermittent administration and could be the best option to treat severe HSV-1 infectious patients.Entities:
Keywords: Allogeneic hematopoietic transplantation; Continuous acyclovir administration; DNA polymerase; Herpes simplex virus 1; Virological resistance
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Year: 2018 PMID： 30064949 DOI： 10.1016/j.jiac.2018.07.004
Source DB: PubMed Journal: J Infect Chemother ISSN： 1341-321X Impact factor: 2.211