A Dautruche1, S Bolle2, L Feuvret3, C Le Tourneau4, T Jouffroy5, F Goudjil6, S Zefkili4, C Nauraye6, J Rodriguez5, P Herman7, V Calugaru4. 1. Radiotherapy Department, institut Curie, 26, rue d'Ulm, 75005 Paris, France. Electronic address: Antoine.Dautruche@gmail.com. 2. Radiotherapy Department, Gustave-Roussy Cancer campus, 114, rue Édouard-Vaillant, 94800 Villejuif, France. 3. Radiotherapy Department, hôpital La Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France. 4. Radiotherapy Department, institut Curie, 26, rue d'Ulm, 75005 Paris, France. 5. Head and Neck Surgery Department, institut Curie, 26, rue d'Ulm, 75005 Paris, France. 6. Medical Physics Department, institut Curie, 15, rue Georges-Clémenceau, 91400 Orsay, France. 7. Head & Neck Surgery Department, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
Abstract
PURPOSE: We report the patient outcomes of a treatment combining proton therapy and Tomotherapy in sinonasal adenoid cystic carcinoma involving skull base. MATERIALS AND METHODS: We included patients treated at Curie Institute, Paris, France, between March 2010 and February 2014 for an advanced adenoid cystic carcinoma involving skull base. Patients received Tomotherapy, proton therapy or both. We evaluated treatment toxicity (according to CTCAE V4), local control, distant metastasis-free survival and overall survival. RESULTS: Thirteen patients were included, with a median follow-up of 34 months. Radiation therapy followed surgery for 77% of the patients and margins were positive in all those cases. Median dose was 73.8Gy. Local control, distant metastasis-free survival and overall survival at 3 years were respectively 60%, 48% and 60%. One-sided grade 3 hearing impairment occurred in 46% of the patients. CONCLUSION: Combining high-dose proton therapy and Tomotherapy is effective and has moderate toxicity in the treatment of T4 sinonasal adenoid cystic carcinoma involving skull base.
PURPOSE: We report the patient outcomes of a treatment combining proton therapy and Tomotherapy in sinonasal adenoid cystic carcinoma involving skull base. MATERIALS AND METHODS: We included patients treated at Curie Institute, Paris, France, between March 2010 and February 2014 for an advanced adenoid cystic carcinoma involving skull base. Patients received Tomotherapy, proton therapy or both. We evaluated treatment toxicity (according to CTCAE V4), local control, distant metastasis-free survival and overall survival. RESULTS: Thirteen patients were included, with a median follow-up of 34 months. Radiation therapy followed surgery for 77% of the patients and margins were positive in all those cases. Median dose was 73.8Gy. Local control, distant metastasis-free survival and overall survival at 3 years were respectively 60%, 48% and 60%. One-sided grade 3 hearing impairment occurred in 46% of the patients. CONCLUSION: Combining high-dose proton therapy and Tomotherapy is effective and has moderate toxicity in the treatment of T4 sinonasal adenoid cystic carcinoma involving skull base.
Authors: Othman Bin-Alamer; Ali S Haider; Adhiraj Chaudhary; Kishore Balasubramanian; Tessa Breeding; Paolo Palmisciano; Maryam Haider; Aaron A Cohen-Gadol; Tarek Y El Ahmadieh; Kenny Yu Journal: Cancer Diagn Progn Date: 2022-09-03
Authors: Julia Schnoell; Lorenz Kadletz; Bernhard J Jank; Felicitas Oberndorfer; Faris F Brkic; Elisabeth Gurnhofer; Julia Cede; Rudolf Seemann; Lukas Kenner; Gregor Heiduschka Journal: Clin Otolaryngol Date: 2020-02-05 Impact factor: 2.597